Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Program Projects (P01)
Project #
5P01DA010156-02
Application #
5209779
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Booker, T K; Butt, Christopher M; Wehner, Jeanne M et al. (2007) Decreased anxiety-like behavior in beta3 nicotinic receptor subunit knockout mice. Pharmacol Biochem Behav 87:146-57
Fonck, Carlos; Cohen, Bruce N; Nashmi, Raad et al. (2005) Novel seizure phenotype and sleep disruptions in knock-in mice with hypersensitive alpha4* nicotinic receptors. J Neurosci 25:11396-411
Wehner, J M; Keller, J J; Keller, A B et al. (2004) Role of neuronal nicotinic receptors in the effects of nicotine and ethanol on contextual fear conditioning. Neuroscience 129:11-24
Fonck, Carlos; Nashmi, Raad; Deshpande, Purnima et al. (2003) Increased sensitivity to agonist-induced seizures, straub tail, and hippocampal theta rhythm in knock-in mice carrying hypersensitive alpha 4 nicotinic receptors. J Neurosci 23:2582-90
Cui, Changhai; Booker, T K; Allen, Roberta S et al. (2003) The beta3 nicotinic receptor subunit: a component of alpha-conotoxin MII-binding nicotinic acetylcholine receptors that modulate dopamine release and related behaviors. J Neurosci 23:11045-53
Dobelis, Peter; Marks, Michael J; Whiteaker, Paul et al. (2002) A polymorphism in the mouse neuronal alpha4 nicotinic receptor subunit results in an alteration in receptor function. Mol Pharmacol 62:334-42
Labarca, C; Schwarz, J; Deshpande, P et al. (2001) Point mutant mice with hypersensitive alpha 4 nicotinic receptors show dopaminergic deficits and increased anxiety. Proc Natl Acad Sci U S A 98:2786-91
Gould, T J; Collins, A C; Wehner, J M (2001) Nicotine enhances latent inhibition and ameliorates ethanol-induced deficits in latent inhibition. Nicotine Tob Res 3:17-24
Vissel, B; Royle, G A; Christie, B R et al. (2001) The role of RNA editing of kainate receptors in synaptic plasticity and seizures. Neuron 29:217-27
Wehner, J M; Radcliffe, R A; Bowers, B J (2001) Quantitative genetics and mouse behavior. Annu Rev Neurosci 24:845-67

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