The Resource Core will enhance the technical elements of this Program by providing the optimal analytical and animal support for all projects in an uniform fashion. This will be achieved by: (1) providing general access to specialized technology which will decrease data reliability and quality; (b) accelerating research analysis; and (c) decreasing expense by providing and maintaining central facilities and services. The two principal components and associated specific aims of the Resource Core are as follows: A. The Resource Core will provide animal support through Animal Resources for the four projects. Animal Resources will oversee purchasing, housing, and some treatment (e.g., microdialysis, cannula placement, and other surgeries) for the laboratory animals used by all of the projects. These operations will placement, and other surgeries) for the laboratory animals used by all of the projects. These operations will be conducted by Animal Resources in order to relieve the individual projects from routine animal management as well as standardized the animal care and treatment. B. The Resource Core will provide highly specialized analytical support for the four projects through Technology Resources. This core will conduct routine analysis of drug and metabolites as well as analysis of neurotransmitters, their metabolites and free radical products. The services to be provided by this core include GC/MS and HPLC operations and maintenance.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Program Projects (P01)
Project #
1P01DA013367-01A1
Application #
6409481
Study Section
Special Emphasis Panel (ZRG1)
Project Start
2001-09-01
Project End
2006-08-31
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost
Name
University of Utah
Department
Type
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
German, Christopher L; Gudheti, Manasa V; Fleckenstein, Annette E et al. (2017) Brain Slice Staining and Preparation for Three-Dimensional Super-Resolution Microscopy. Methods Mol Biol 1663:153-162
Baladi, Michelle G; Nielsen, Shannon M; McIntosh, J Michael et al. (2016) Prior nicotine self-administration attenuates subsequent dopaminergic deficits of methamphetamine in rats: role of nicotinic acetylcholine receptors. Behav Pharmacol 27:422-30
Fricks-Gleason, Ashley N; German, Christopher L; Hoonakker, Amanda J et al. (2016) An acute, epitope-specific modification in the dopamine transporter associated with methamphetamine-induced neurotoxicity. Synapse 70:139-46
Alburges, Mario E; Hoonakker, Amanda J; Cordova, Nathaniel M et al. (2015) Effect of low doses of methamphetamine on rat limbic-related neurotensin systems. Synapse 69:396-404
Vieira-Brock, Paula L; McFadden, Lisa M; Nielsen, Shannon M et al. (2015) Nicotine Administration Attenuates Methamphetamine-Induced Novel Object Recognition Deficits. Int J Neuropsychopharmacol 18:
McFadden, Lisa M; Vieira-Brock, Paula L; Hanson, Glen R et al. (2015) Prior methamphetamine self-administration attenuates the dopaminergic deficits caused by a subsequent methamphetamine exposure. Neuropharmacology 93:146-54
German, Christopher L; Baladi, Michelle G; McFadden, Lisa M et al. (2015) Regulation of the Dopamine and Vesicular Monoamine Transporters: Pharmacological Targets and Implications for Disease. Pharmacol Rev 67:1005-24
Vieira-Brock, Paula L; McFadden, Lisa M; Nielsen, Shannon M et al. (2015) Chronic Nicotine Exposure Attenuates Methamphetamine-Induced Dopaminergic Deficits. J Pharmacol Exp Ther 355:463-72
German, Christopher L; Fleckenstein, Annette E; Hanson, Glen R (2014) Bath salts and synthetic cathinones: an emerging designer drug phenomenon. Life Sci 97:2-8
Baladi, Michelle G; Nielsen, Shannon M; Umpierre, Anthony et al. (2014) Prior methylphenidate self-administration alters the subsequent reinforcing effects of methamphetamine in rats. Behav Pharmacol 25:758-65

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