Abstract

There are two fundamental reasons to extend studies of CSF biomarkers in HIV to include proteomic studies: to address some of the major unanswered questions about pathogenesis, and to develop better tools for predicting, diagnosing and managing the neurological effects of infection (112, 113). These are inter-related, since understanding pathogenesis and the nature and 'behavior'of individual biomarkers will inform their use in patient management.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Program Projects (P01)
Project #
5P01DA026134-03
Application #
8077972
Study Section
Special Emphasis Panel (ZDA1)
Project Start
Project End
Budget Start
2010-06-01
Budget End
2012-05-31
Support Year
3
Fiscal Year
2010
Total Cost
$212,429
Indirect Cost

  Institution

Name
Battelle Pacific Northwest Laboratories
Department
Type
DUNS #
032987476
City
Richland
State
WA
Country
United States
Zip Code
99352

  Publications

Premeaux, Thomas A; D'Antoni, Michelle L; Abdel-Mohsen, Mohamed et al. (2018) Elevated cerebrospinal fluid Galectin-9 is associated with central nervous system immune activation and poor cognitive performance in older HIV-infected individuals. J Neurovirol :
Peterson, Julia; Gisslen, Magnus; Zetterberg, Henrik et al. (2014) Cerebrospinal fluid (CSF) neuronal biomarkers across the spectrum of HIV infection: hierarchy of injury and detection. PLoS One 9:e116081
Dominy, Stephen S; Brown, Joseph N; Ryder, Mark I et al. (2014) Proteomic analysis of saliva in HIV-positive heroin addicts reveals proteins correlated with cognition. PLoS One 9:e89366
Price, Richard W; Spudich, Serena S; Peterson, Julia et al. (2014) Evolving character of chronic central nervous system HIV infection. Semin Neurol 34:7-13
Grund, Birgit; Wright, Edwina J; Brew, Bruce J et al. (2013) Improved neurocognitive test performance in both arms of the SMART study: impact of practice effect. J Neurovirol 19:383-92
Price, Richard W; Peterson, Julia; Fuchs, Dietmar et al. (2013) Approach to cerebrospinal fluid (CSF) biomarker discovery and evaluation in HIV infection. J Neuroimmune Pharmacol 8:1147-58
Piehowski, Paul D; Petyuk, Vladislav A; Sandoval, John D et al. (2013) STEPS: a grid search methodology for optimized peptide identification filtering of MS/MS database search results. Proteomics 13:766-70
Brown, Joseph N; Ortiz, Gabriel M; Angel, Thomas E et al. (2012) Morphine produces immunosuppressive effects in nonhuman primates at the proteomic and cellular levels. Mol Cell Proteomics 11:605-18