The long-term goal of the Rocky Mountain Taste & Smell Center is to gain a thorough understanding of transduction and intercellular interactions in chemosensory epithelia under normal, and disease conditions. To achieve this aim, our studies are first conducted in animal mode systems, then extended to humans when feasible. The six projects contained here, which examine both human and animal systems, are interrelated by transmission, and phenotype acquisition. In four of the projects, a primary focus is stimulus transduction. Inhibitory odorant responses and sweet taste transduction will be studied using electrophysiological and functional imaging techniques in two projects; another project will examine the role that functional changes in olfactory receptor neurons may play in steroid- dependent anosmia in humans, and finally transduction of intraepithelial chemical signals mediating development of taste buds will be studied. This last project is one of three projects which focus on development and regeneration of taste buds will be studied, the proposal's second major theme. The other two projects in this group examine synaptogenesis and synaptic specificity, and the events underlying functional and anatomical recovery of taste in humans following post-irradiation dysgeusia. The third programmatic theme involves synaptic transmission between taste receptor cells and the primary functional correlates of vesicular release of neurotransmitter from taste cells and seek to identify the neurotransmitter(s) released from taste receptor cells onto their afferent nerves. The four theme, phenotype acquisition and characterization, relates four projects. This projects will study whether the morphological and histochemical phenotypes of taste cells relate to cell lineage, relative age, state of innervation or to a functional state of the receptor cells. The projects of the Rocky Mountain Taste and Smell Center involve collaborative, interdisciplinary efforts and address several important questions in the field of chemosensory research. The shared expertise and related interests of the investigators brought together in this Center facilitate approaches to questions hitherto intractable by a single methodology or laboratory.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Program Projects (P01)
Project #
5P01DC000244-17
Application #
6379220
Study Section
Special Emphasis Panel (ZDC1-SRB-F (17))
Program Officer
Davis, Barry
Project Start
1984-04-01
Project End
2003-03-31
Budget Start
2001-04-01
Budget End
2002-03-31
Support Year
17
Fiscal Year
2001
Total Cost
$803,155
Indirect Cost
Name
University of Colorado Denver
Department
Biology
Type
Schools of Medicine
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Finger, Thomas E; Bartel, Dianna L; Shultz, Nicole et al. (2017) 5HTR3A-driven GFP labels immature olfactory sensory neurons. J Comp Neurol 525:1743-1755
Tizzano, Marco; Finger, Thomas E (2013) Chemosensors in the nose: guardians of the airways. Physiology (Bethesda) 28:51-60
Finger, Thomas E (2009) Evolution of gustatory reflex systems in the brainstems of fishes. Integr Zool 4:53-63
Ikenaga, Takanori; Ogura, Tatsuya; Finger, Thomas E (2009) Vagal gustatory reflex circuits for intraoral food sorting behavior in the goldfish: cellular organization and neurotransmitters. J Comp Neurol 516:213-25
Finger, Thomas E (2008) Sorting food from stones: the vagal taste system in Goldfish, Carassius auratus. J Comp Physiol A Neuroethol Sens Neural Behav Physiol 194:135-43
Huesa, Gema; Ikenaga, Takanori; Bottger, Barbel et al. (2008) Calcium-fluxing glutamate receptors associated with primary gustatory afferent terminals in goldfish (Carassius auratus). J Comp Neurol 506:694-707
Yee, Cindy; Bartel, Dianna L; Finger, Thomas E (2005) Effects of glossopharyngeal nerve section on the expression of neurotrophins and their receptors in lingual taste buds of adult mice. J Comp Neurol 490:371-90
Linschoten, Miriam R; Harvey Jr, Lewis O (2004) Detecting malingerers by means of response-sequence analysis. Percept Psychophys 66:1190-201
Hall, Joshua M H; Bell, Melanie L; Finger, Thomas E (2003) Disruption of sonic hedgehog signaling alters growth and patterning of lingual taste papillae. Dev Biol 255:263-77
Finger, Thomas E; Bottger, Barbel; Hansen, Anne et al. (2003) Solitary chemoreceptor cells in the nasal cavity serve as sentinels of respiration. Proc Natl Acad Sci U S A 100:8981-6

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