Abstract

This application proposes five inter-related studies of Auditory Mechanisms at the chemical-molecular, genetic, and neural levels. Project I plans to study chemical-molecular mechanisms which affect afferent and efferent responses as well as distortion product emissions in the ear. Otoacoustic emissions and the development of their susceptibility to contralateral stimulation are the targets for Project III, along with selected clinical and genetic studies. Genetic studies are the focus of Project II and parts of Project IV, which also proposes to study the Trophic effects of GM-1 Gangliosides on genetically and artificially deafened mice. Project V plans to study the trophic effects in deaf animals of GM-1 gangliosides when combined with electrical stimulation using cochlear implants.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Program Projects (P01)
Project #
2P01DC000379-06A1
Application #
3094853
Study Section
Communication Disorders Review Committee (CDRC)
Project Start
1986-12-01
Project End
1997-06-30
Budget Start
1992-07-01
Budget End
1993-06-30
Support Year
6
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Louisiana State University Hsc New Orleans
Department
Type
Schools of Medicine
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112

  Publications

Hurley, Raymond M; Hurley, Annette; Berlin, Charles I (2005) Development of low-frequency tone burst versus the click auditory brainstem response. J Am Acad Audiol 16:114-21; Quiz 122
Hurley, Raymond M; Hurley, Annette; Berlin, Charles I (2002) The effect of midline petrous apex lesions on tests of afferent and efferent auditory function. Ear Hear 23:224-34
Ruel, J; Bobbin, R P; Vidal, D et al. (2000) The selective AMPA receptor antagonist GYKI 53784 blocks action potential generation and excitotoxicity in the guinea pig cochlea. Neuropharmacology 39:1959-73
Scott, D A; Drury, S; Sundstrom, R A et al. (2000) Refining the DFNB7-DFNB11 deafness locus using intragenic polymorphisms in a novel gene, TMEM2. Gene 246:265-74
Li, L; Parkins, C W; Webster, D B (1999) Does electrical stimulation of deaf cochleae prevent spiral ganglion degeneration? Hear Res 133:27-39
Ruel, J; Chen, C; Pujol, R et al. (1999) AMPA-preferring glutamate receptors in cochlear physiology of adult guinea-pig. J Physiol 518 ( Pt 3):667-80
Scott, D A; Greinwald Jr, J H; Marietta, J R et al. (1998) Identification and mutation analysis of a cochlear-expressed, zinc finger protein gene at the DFNB7/11 and dn hearing-loss loci on human chromosome 9q and mouse chromosome 19. Gene 215:461-9
Parker, M S; Larroque, M L; Campbell, J M et al. (1998) Novel variant of the P2X2 ATP receptor from the guinea pig organ of Corti. Hear Res 121:62-70
Chen, C; Skellett, R A; Fallon, M et al. (1998) Additional pharmacological evidence that endogenous ATP modulates cochlear mechanics. Hear Res 118:47-61
Skellett, R A; Cullen Jr, J K; Fallon, M et al. (1998) Conditioning the auditory system with continuous vs. interrupted noise of equal acoustic energy: is either exposure more protective? Hear Res 116:21-32

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