This application proposes five inter-related studies of Auditory Mechanisms at the chemical-molecular, genetic, and neural levels. Project I plans to study chemical-molecular mechanisms which affect afferent and efferent responses as well as distortion product emissions in the ear. Otoacoustic emissions and the development of their susceptibility to contralateral stimulation are the targets for Project III, along with selected clinical and genetic studies. Genetic studies are the focus of Project II and parts of Project IV, which also proposes to study the Trophic effects of GM-1 Gangliosides on genetically and artificially deafened mice. Project V plans to study the trophic effects in deaf animals of GM-1 gangliosides when combined with electrical stimulation using cochlear implants.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Research Program Projects (P01)
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Communication Disorders Review Committee (CDRC)
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Louisiana State University Hsc New Orleans
Schools of Medicine
New Orleans
United States
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Hurley, Raymond M; Hurley, Annette; Berlin, Charles I (2005) Development of low-frequency tone burst versus the click auditory brainstem response. J Am Acad Audiol 16:114-21; Quiz 122
Hurley, Raymond M; Hurley, Annette; Berlin, Charles I (2002) The effect of midline petrous apex lesions on tests of afferent and efferent auditory function. Ear Hear 23:224-34
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Skellett, R A; Cullen Jr, J K; Fallon, M et al. (1998) Conditioning the auditory system with continuous vs. interrupted noise of equal acoustic energy: is either exposure more protective? Hear Res 116:21-32

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