Abstract

This application proposes a thorough study of the stages of development of the nose and ear using Xenopus laevis as a model system. Studies including fate mapping, embryo transplantation and explantation experiments will define the early tissue interactions that lead to the formation of the olfactory epithelium. The experiments in the auditory system will focus on tissue interactions that lead to formation of the highly regionalized tissues within the inner ear. These experiments will provide information on the hypothesis that all sensory tissues are determined by common mechanisms and will provide a basis for undertaking studies to identify the signaling molecules that control sensory tissue development.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Program Projects (P01)
Project #
5P01DC003576-04
Application #
6651286
Study Section
Communication Disorders Review Committee (CDRC)
Project Start
2002-04-01
Project End
2003-03-31
Budget Start
Budget End
Support Year
4
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of Virginia
Department
Type
DUNS #
001910777
City
Charlottesville
State
VA
Country
United States
Zip Code
22904

  Publications

Lee, Kenneth H; Warchol, Mark E (2008) Promotion of neurite outgrowth and axon guidance in spiral ganglion cells by netrin-1. Arch Otolaryngol Head Neck Surg 134:146-51
Hill, David L (2005) Nerve-target interactions in the gustatory system following unilateral chorda tympani nerve section. Chem Senses 30 Suppl 1:i64-5
Lee, Kenneth H; Warchol, Mark E (2005) Ephrin A2 may play a role in axon guidance during hair cell regeneration. Laryngoscope 115:1021-5
Matsui, Jonathan I; Gale, Jonathan E; Warchol, Mark E (2004) Critical signaling events during the aminoglycoside-induced death of sensory hair cells in vitro. J Neurobiol 61:250-66
Cunningham, Lisa L; Matsui, Jonathan I; Warchol, Mark E et al. (2004) Overexpression of Bcl-2 prevents neomycin-induced hair cell death and caspase-9 activation in the adult mouse utricle in vitro. J Neurobiol 60:89-100
Hill, David L (2004) Neural plasticity in the gustatory system. Nutr Rev 62:S208-17; discussion S224-41
Shuler, Marshall G; Krimm, Robin F; Hill, David L (2004) Neuron/target plasticity in the peripheral gustatory system. J Comp Neurol 472:183-92
Hawkins, R David; Bashiardes, Stavros; Helms, Cynthia A et al. (2003) Gene expression differences in quiescent versus regenerating hair cells of avian sensory epithelia: implications for human hearing and balance disorders. Hum Mol Genet 12:1261-72
Matsui, Jonathan I; Haque, Asim; Huss, David et al. (2003) Caspase inhibitors promote vestibular hair cell survival and function after aminoglycoside treatment in vivo. J Neurosci 23:6111-22
Noramly, Selina; Grainger, Robert M (2002) Determination of the embryonic inner ear. J Neurobiol 53:100-28

Showing the most recent 10 out of 16 publications