Abstract

This proposal presents a broad program whose goal is to provide key pieces of basic information required to better understand the etiology and pathogenesis of dental caries and various forms of periodontal disease, and to formulate rational approaches for their control. The program integrates the efforts of investigators experienced in the areas of microbiology, animal experimentation, electron microscopy, nutrition, periodontology and clinical dentistry, and represents an extension of on-going studies.
The specific aims i nclude attempts to develop and refine methodology for studying important oral bacteria, and studies of the properties of odontopathic bacteria which account for, or influence their virulence.
Other aims relate to elucidating parameters which influence the transmission and acquisition of prominent oral bacteria. Special emphasis is being devoted to studies of host and environmental factors which affect the colonization of potentially- important odontopathic bacteria. Included are studies of the influence of dietary components, topically-applied fluorides, polymorphonuclear leucocytes and their products, certain antibodies, intraoral location, and fibronectin on oral microbial colonization.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Program Projects (P01)
Project #
5P01DE002847-21
Application #
3094918
Study Section
(SSS)
Project Start
1978-09-01
Project End
1992-08-31
Budget Start
1989-09-01
Budget End
1990-08-31
Support Year
21
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
Forsyth Institute
Department
Type
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02142

  Publications

Niederman, R; Naleway, C; Lu, B Y et al. (1995) Subgingival temperature as a gingival inflammatory indicator. J Clin Periodontol 22:804-9
Duncan, M J; Nakao, S; Skobe, Z et al. (1993) Interactions of Porphyromonas gingivalis with epithelial cells. Infect Immun 61:2260-5
Haffajee, A D; Socransky, S S; Smith, C et al. (1992) The use of DNA probes to examine the distribution of subgingival species in subjects with different levels of periodontal destruction. J Clin Periodontol 19:84-91
Haffajee, A D; Socransky, S S (1992) Effect of sampling strategy on the false-negative rate for detection of selected subgingival species. Oral Microbiol Immunol 7:57-9
Haffajee, A D; Socransky, S S; Smith, C et al. (1992) Subgingival temperature (III). Relation to microbial counts. J Clin Periodontol 19:417-22
Haffajee, A D; Socransky, S S; Goodson, J M (1992) Subgingival temperature (I). Relation to baseline clinical parameters. J Clin Periodontol 19:401-8
Socransky, S S; Haffajee, A D (1992) The bacterial etiology of destructive periodontal disease: current concepts. J Periodontol 63:322-31
Haffajee, A D; Socransky, S S; Goodson, J M (1992) Subgingival temperature (II). Relation to future periodontal attachment loss. J Clin Periodontol 19:409-16
Socransky, S S; Haffajee, A D (1991) Microbial mechanisms in the pathogenesis of destructive periodontal diseases: a critical assessment. J Periodontal Res 26:195-212
Gibbons, R J; Hay, D I; Schlesinger, D H (1991) Delineation of a segment of adsorbed salivary acidic proline-rich proteins which promotes adhesion of Streptococcus gordonii to apatitic surfaces. Infect Immun 59:2948-54

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