This revised application requests a second 5-year period of support for a program project having the following general goals: (1) to assess the utility of approaches, instrumentation, and analysis procedures designed to enable identification and quantification of central somatosensory nervous system adaptive mechanisms in normal human subjects as well as in patient populations with orofacial sensory dysfunction; and (2) to evaluate experimentally the hypothesis that in a variety of orofacial sensory disorders (including temporomandibular disorders - TMD) the dynamic neural mechanisms which normally operate to adaptively modify the somatosensory cerebral cortical response to maintained (""""""""tonic"""""""") somatic afferent drive function in an abnormal and maladaptive manner. The skills, prior experiences, and interests of the participating investigators are consistent with the goals proposed: collectively, the assembled research team possesses a considerable record of contributions to somatosensory neurophysiology and human psychophysics, and includes appropriate expertise in the evaluation, management, and treatment of clinical pain populations. The program involves five independent, but inter-related projects, all interacting closely with a core designed (1) to provide the number of thoroughly screened, adequately protected, and fully clinically- characterized human subjects required to satisfy project and program goals, (2) to make readily available to each project high quality and appropriate statistical and computational support, (3) to stimulate sharing and integration of the information obtained by the different projects and interpretation of that information in terms of the neural mechanisms underlying chronic orofacial sensory dysfunction, and finally, (4) to provide essential administrative support, coordination, and scientific leadership.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Program Projects (P01)
Project #
5P01DE007509-08
Application #
2129849
Study Section
Special Emphasis Panel (SRC (01))
Project Start
1986-07-01
Project End
1997-03-31
Budget Start
1994-04-01
Budget End
1995-03-31
Support Year
8
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Dentistry
Type
Schools of Dentistry
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Bair, Eric; Simmons, Elizabeth; Hartung, Jessica et al. (2015) Natural history of comorbid orofacial pain among women with vestibulodynia. Clin J Pain 31:73-8
Zolnoun, Denniz; Bair, Eric; Essick, Greg et al. (2012) Reliability and reproducibility of novel methodology for assessment of pressure pain sensitivity in pelvis. J Pain 13:910-20
Lim, Pei Feng; Smith, Shad; Bhalang, Kanokporn et al. (2010) Development of temporomandibular disorders is associated with greater bodily pain experience. Clin J Pain 26:116-20
McLean, Samuel A; Kirsch, Ned L; Tan-Schriner, Cheribeth U et al. (2009) Health status, not head injury, predicts concussion symptoms after minor injury. Am J Emerg Med 27:182-90
Slade, Gary D; Diatchenko, Luda; Ohrbach, Richard et al. (2008) Orthodontic Treatment, Genetic Factors and Risk of Temporomandibular Disorder. Semin Orthod 14:146-156
Diatchenko, Luda; Slade, Gary D; Nackley, Andrea G et al. (2007) Responses to Drs. Kim and Dionne regarding comments on Diatchenko, et al. Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain 2006;125: 216-24. Pain 129:366-370
Diatchenko, Luda; Anderson, Amy D; Slade, Gary D et al. (2006) Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder. Am J Med Genet B Neuropsychiatr Genet 141B:449-62
BensmaIa, Sliman J; Hollins, Mark (2003) The vibrations of texture. Somatosens Mot Res 20:33-43
Whitsel, B L; Kelly, E F; Quibrera, M et al. (2003) Time-dependence of SI RA neuron response to cutaneous flutter stimulation. Somatosens Mot Res 20:45-69
Whitsel, B L; Kelly, E F; Xu, M et al. (2001) Frequency-dependent response of SI RA-class neurons to vibrotactile stimulation of the receptive field. Somatosens Mot Res 18:263-85

Showing the most recent 10 out of 13 publications