The primary responsibility of the Clinical Core is to facilitate the scientific progress of Subprojects 1-4 by providing them with orofacial sensory disorder patients and age and gender-matched controls for participation in their experimental protocols. The Clinical Core was developed during the current funding period and has been quite successful in recruiting and evaluating patients with temporomandibular disorder (TMD) and trigeminal nerve injury, as well as healthy controls, for participation in experimental studies. During the funding period requested by this proposal, the Clinical Core will provide the following services: 1) Recruitment of TMD and trigeminal nerve injury patients and controls, 2) Clinical diagnostic evaluations of patients and controls, and 3) Maintaining a database of demographic, clinical, and psychosocial information on TMD and nerve injury patients and controls. Clear and effective mechanisms for each of these activities have been well established and will continue to be implemented during the next funding period. The Clinical Core will provide all relevant demographic, clinical and psychosocial data to the individual Subprojects to assist them in the conduct of their studies and interpretation of their experimental findings. The central Clinical Core represents the most efficient and scientifically efficacious mechanism for meeting the patient management needs of Subprojects 1-4.

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University of North Carolina Chapel Hill
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Bair, Eric; Simmons, Elizabeth; Hartung, Jessica et al. (2015) Natural history of comorbid orofacial pain among women with vestibulodynia. Clin J Pain 31:73-8
Zolnoun, Denniz; Bair, Eric; Essick, Greg et al. (2012) Reliability and reproducibility of novel methodology for assessment of pressure pain sensitivity in pelvis. J Pain 13:910-20
Lim, Pei Feng; Smith, Shad; Bhalang, Kanokporn et al. (2010) Development of temporomandibular disorders is associated with greater bodily pain experience. Clin J Pain 26:116-20
McLean, Samuel A; Kirsch, Ned L; Tan-Schriner, Cheribeth U et al. (2009) Health status, not head injury, predicts concussion symptoms after minor injury. Am J Emerg Med 27:182-90
Slade, Gary D; Diatchenko, Luda; Ohrbach, Richard et al. (2008) Orthodontic Treatment, Genetic Factors and Risk of Temporomandibular Disorder. Semin Orthod 14:146-156
Diatchenko, Luda; Slade, Gary D; Nackley, Andrea G et al. (2007) Responses to Drs. Kim and Dionne regarding comments on Diatchenko, et al. Catechol-O-methyltransferase gene polymorphisms are associated with multiple pain-evoking stimuli. Pain 2006;125: 216-24. Pain 129:366-370
Diatchenko, Luda; Anderson, Amy D; Slade, Gary D et al. (2006) Three major haplotypes of the beta2 adrenergic receptor define psychological profile, blood pressure, and the risk for development of a common musculoskeletal pain disorder. Am J Med Genet B Neuropsychiatr Genet 141B:449-62
Whitsel, B L; Kelly, E F; Quibrera, M et al. (2003) Time-dependence of SI RA neuron response to cutaneous flutter stimulation. Somatosens Mot Res 20:45-69
BensmaIa, Sliman J; Hollins, Mark (2003) The vibrations of texture. Somatosens Mot Res 20:33-43
Whitsel, B L; Kelly, E F; Xu, M et al. (2001) Frequency-dependent response of SI RA-class neurons to vibrotactile stimulation of the receptive field. Somatosens Mot Res 18:263-85

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