Abstract

This Program Project Grant application has been initiated in order to utilize the expertise in our institution to clarify the mechanisms by which bone cell function is disordered in diseases of the oral cavity. It is our contention that the mechanisms by which disease process of the oral cavity affect alveolar bone is by the generation of soluble factors which stimulate bone cells.
The specific aims of this application are to identify the mechanisms by which disease processes in the oral cavity affect bone resorbing and bone forming cells, and our plan is to use in vitro techniques of cell culture and organ culture as well as in vivo studies to assess the effects of potential mediators on bone resorption and bone formation. These mechanisms and factors are heterogeneous, and characterization of the pathophysiology of bone cell dysfunction in these diseases will require a broadly-based approach. Since the expertise required to identify and clarify these mechanisms will require the attention of investigators with different types of skills, a team approach will be used to unite these different approaches around the tightly focused goal of clarifying the pathophysiology of bone cell dysfunction in diseases of the oral cavity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Program Projects (P01)
Project #
5P01DE008569-04
Application #
3095033
Study Section
Special Emphasis Panel (SSS (08))
Project Start
1989-01-01
Project End
1993-12-31
Budget Start
1992-01-01
Budget End
1992-12-31
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
University of Texas Health Science Center San Antonio
Department
Type
Schools of Dentistry
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229

  Publications

Zubery, Y; Dunstan, C R; Story, B M et al. (1998) Bone resorption caused by three periodontal pathogens in vivo in mice is mediated in part by prostaglandin. Infect Immun 66:4158-62
Izbicka, E; Yoneda, T; Takaoka, Y et al. (1996) Identification of a novel bone/calcium metabolism-regulating factor in porcine pancreas. J Biol Chem 271:23230-4
Garcia, C; Boyce, B F; Gilles, J et al. (1996) Leukotriene B4 stimulates osteoclastic bone resorption both in vitro and in vivo. J Bone Miner Res 11:1619-27
Marra, F; Bonewald, L F; Park-Snyder, S et al. (1996) Characterization and regulation of the latent transforming growth factor-beta complex secreted by vascular pericytes. J Cell Physiol 166:537-46
de la Mata, J; Uy, H L; Guise, T A et al. (1995) Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo. J Clin Invest 95:2846-52
Hughes, D E; Wright, K R; Uy, H L et al. (1995) Bisphosphonates promote apoptosis in murine osteoclasts in vitro and in vivo. J Bone Miner Res 10:1478-87
Boyce, B F; Wright, K; Reddy, S V et al. (1995) Targeting simian virus 40 T antigen to the osteoclast in transgenic mice causes osteoclast tumors and transformation and apoptosis of osteoclasts. Endocrinology 136:5751-9
Mundy, G R (1994) Peptides and growth regulatory factors in bone. Rheum Dis Clin North Am 20:577-88
Harris, S E; Bonewald, L F; Harris, M A et al. (1994) Effects of transforming growth factor beta on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts. J Bone Miner Res 9:855-63
Yoneda, T; Takaoka, Y; Boyce, B F et al. (1994) Extracts of porcine pancreas prevent progression of hypercalcemia and cachexia and prolong survival in nude mice bearing a human squamous carcinoma. Cancer Res 54:2509-13

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