Core-- Immunopathology

Aufdemorte, Thomas B.

Abstract

The Immunopathology Core will be established to provide histopathology processing and analysis of experimental and clinical tissue specimens. Immunocytochemical analysis will be performed to evaluate the various cytokines and immunoglobulins associated with the pathogenesis of Sjogren's syndrome. In addition, quantitative histomorphometric analysis for Sjogren's focus scoring and semi-quantitated immunohistochemical analysis will be performed. The Immunopathology Core will be staffed by Drs. Thomas B. Aufdemorte and H. Stan McGuff of the Department of Pathology. They will be responsible for overseeing the technical and scientific components of the core, as well as performing pathological analysis of experimental specimens. Other services available within the Immunopathology Core to support and expand the program research efforts include molecular diagnostics, flow cytometry and electron microscopy. The Immunopathology Core is already functioning as a clinical resource to the Department of Medicine and Immunology and with minimal expansion of technical staff will provide a central, efficient, cost effective source for the programs experimental pathology needs.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Dental & Craniofacial Research (NIDCR)
• Type: Research Program Projects (P01)
• Project #: 5P01DE010863-05
• Application #: 6104881
• Project Start: 1998-03-01
• Project End: 2000-02-29
• Support Year: 5
• Fiscal Year: 1998

Institution

• Name: University of Texas Health Science Center San Antonio
• DUNS #: 800772162
• City: San Antonio
• State: TX
• Country: United States
• Zip Code: 78229

Publications

Ebersole, Jeffrey L; Cappelli, David; Mathys, Erik C et al. (2002) Periodontitis in humans and non-human primates: oral-systemic linkage inducing acute phase proteins. Ann Periodontol 7:102-11

Liu, X B; Masago, R; Kong, L et al. (2000) G-protein signaling abnormalities mediated by CD95 in salivary epithelial cells. Cell Death Differ 7:1119-26

Sakata, K; Sakata, A; Kong, L et al. (1999) Monocyte rescue of human T cells from apoptosis is CD40/CD154 dependent. Scand J Immunol 50:479-84

Celenligil-Nazliel, H; Kansu, E; Ebersole, J L (1999) Periodontal findings and systemic antibody responses to oral microorganisms in Behcet's disease. J Periodontol 70:1449-56

Sakata, K; Sakata, A; Vela-Roch, N et al. (1998) Fas (CD95)-transduced signal preferentially stimulates lupus peripheral T lymphocytes. Eur J Immunol 28:2648-60

Attias, M R; Kong, L; Tortolero, M et al. (1998) CD4 mononuclear cell infiltrates and Fas/Fas ligand positive mammary gland cells in breast tissue from a patient with Sjogren's syndrome. J Rheumatol 25:1226-31

Venkatraman, J T; Angkeow, P; Satsangi, N et al. (1998) Effects of dietary n-6 and n-3 lipids on antioxidant defense system in livers of exercised rats. J Am Coll Nutr 17:586-94

Kong, L; Ogawa, N; McGuff, H S et al. (1998) Bcl-2 family expression in salivary glands from patients with primary Sjogren's syndrome: involvement of Bax in salivary gland destruction. Clin Immunol Immunopathol 88:133-41

Celenligil, H; Eratalay, K; Kansu, E et al. (1998) Periodontal status and serum antibody responses to oral microorganisms in Sjogren's syndrome. J Periodontol 69:571-7

Sakata, K; Sakata, A; Kong, L et al. (1998) Role of Fas/FasL interaction in physiology and pathology: the good and the bad. Clin Immunol Immunopathol 87:1-7