Abstract

The Cell Imaging Core will provide access to state of the art electron and confocal laser scanning microscopes. These instruments are housed in the Medical School Cell Imaging Facility located in the Ward building. This is easily accessible by all members of the projects.
In Aim 1, Core staff will process specimens for conventional electron microscopy. This will involve providing investigators from all four projects with stained sections ready to be viewed in the electron microscope housed in the Core. In addition in Aim 2, Core staff will process protein specimens for rotary shadowing and/or negative stain electron microscopy.
In aim 3, staff members and the Core Principal investigator will provide expert assistance in the analyses of live and fixed specimens which will be viewed by confocal laser scanning light microscopy.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Program Projects (P01)
Project #
2P01DE012328-06
Application #
6535943
Study Section
Special Emphasis Panel (ZDE1-LK (07))
Project Start
1997-08-01
Project End
2007-02-28
Budget Start
1997-08-01
Budget End
2007-02-28
Support Year
6
Fiscal Year
2002
Total Cost
$37,276
Indirect Cost

  Institution

Name
Northwestern University at Chicago
Department
Type
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611

  Publications

Godsel, Lisa M; Hobbs, Ryan P; Green, Kathleen J (2008) Intermediate filament assembly: dynamics to disease. Trends Cell Biol 18:28-37
Dusek, Rachel L; Godsel, Lisa M; Green, Kathleen J (2007) Discriminating roles of desmosomal cadherins: beyond desmosomal adhesion. J Dermatol Sci 45:7-21
Green, Kathleen J; Simpson, Cory L (2007) Desmosomes: new perspectives on a classic. J Invest Dermatol 127:2499-515
Dusek, Rachel L; Getsios, Spiro; Chen, Feng et al. (2006) The differentiation-dependent desmosomal cadherin desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytes. J Biol Chem 281:3614-24
Ghosh, Supurna; Johnson, Jeff J; Sen, Ratna et al. (2006) Functional relevance of urinary-type plasminogen activator receptor-alpha3beta1 integrin association in proteinase regulatory pathways. J Biol Chem 281:13021-9
Munshi, H G; Stack, M S (2006) Reciprocal interactions between adhesion receptor signaling and MMP regulation. Cancer Metastasis Rev 25:45-56
Natarajan, Easwar; Omobono 2nd, John D; Guo, Zongyou et al. (2006) A keratinocyte hypermotility/growth-arrest response involving laminin 5 and p16INK4A activated in wound healing and senescence. Am J Pathol 168:1821-37
Godsel, Lisa M; Hsieh, Sherry N; Amargo, Evangeline V et al. (2005) Desmoplakin assembly dynamics in four dimensions: multiple phases differentially regulated by intermediate filaments and actin. J Cell Biol 171:1045-59
Yin, Taofei; Getsios, Spiro; Caldelari, Reto et al. (2005) Plakoglobin suppresses keratinocyte motility through both cell-cell adhesion-dependent and -independent mechanisms. Proc Natl Acad Sci U S A 102:5420-5
Green, Kathleen J; Bohringer, Michael; Gocken, Todd et al. (2005) Intermediate filament associated proteins. Adv Protein Chem 70:143-202

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