This project seeks to evaluate the most promising means to eradicate infections caused by 0eriodontal disease pathogens. Considering that scaling and root planing (SRP) is likely to be essential to rid sites of plaque biofilms and infected calculus, four adjunctive strategies appear likely to substantially contribute to the transmission, disinfection of pathogen reservoirs and elimination of environments that support growth of periodontal pathogens. Based on a review of microbiologic responses described in our previous studies and in the literature, the strategies most likely to eliminate or suppress the periodontal pathogens were identified. Reduction of supragingival plaque will be achieved by providing powered toothbrushes and triclosan/co-polymer dentifrice to all subjects. Control of pathogen transmission will be by chlorhexidine (CHX) mouth-rinses for two weeks following completion of therapy. Disinfection of pathogen reservoirs will be by application of tetracycline (TC) fibers in all pockets > 3mm. Elimination of environments that support growth of periodontal pathogens will be by periodontal surgery. The proposal describes a unique 2/3 factorial design in which local antibiotics, systemic antibiotics and periodontal surgery will be compared as adjunctive treatments following SRP in subjects receiving electric toothbrushes and triclosan-co-polymer dentifrice. The experimental design provides the potential for high statistical sensitivity by evaluating main effects through combined analysis of 4 of the 8 experimental groups. In addition, the model provides a means to evaluate important interactions between each of the treatments being tested. Although this study addresses important questions related to clinical practice, it also provides information on biological effects of various forms of therapy and identifies the most important directions to be taken in future investigations.

Project Start
2002-06-01
Project End
2003-05-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
4
Fiscal Year
2002
Total Cost
$199,599
Indirect Cost
Name
Forsyth Institute
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02142
Mdala, Ibrahimu; Olsen, Ingar; Haffajee, Anne D et al. (2014) Comparing clinical attachment level and pocket depth for predicting periodontal disease progression in healthy sites of patients with chronic periodontitis using multi-state Markov models. J Clin Periodontol 41:837-45
Socransky, Sigmund S; Haffajee, Anne D; Teles, Ricardo et al. (2013) Effect of periodontal therapy on the subgingival microbiota over a 2-year monitoring period. I. Overall effect and kinetics of change. J Clin Periodontol 40:771-80
Goodson, J Max; Haffajee, Anne D; Socransky, Sigmund S et al. (2012) Control of periodontal infections: a randomized controlled trial I. The primary outcome attachment gain and pocket depth reduction at treated sites. J Clin Periodontol 39:526-36
Teles, Ricardo P; Sakellari, Dimitra; Konstantinidis, Antonis et al. (2009) Application of the checkerboard immunoblotting technique to the quantification of host biomarkers in gingival crevicular fluid. J Periodontol 80:447-56
Teles, R P; Likhari, V; Socransky, S S et al. (2009) Salivary cytokine levels in subjects with chronic periodontitis and in periodontally healthy individuals: a cross-sectional study. J Periodontal Res 44:411-7
Haffajee, Anne D; Socransky, Sigmund Sidney (2009) Relation of body mass index, periodontitis and Tannerella forsythia. J Clin Periodontol 36:89-99
Bogren, Anna; Teles, Ricardo P; Torresyap, Gay et al. (2008) Locally delivered doxycycline during supportive periodontal therapy: a 3-year study. J Periodontol 79:827-35
Teles, R P; Patel, M; Socransky, S S et al. (2008) Disease progression in periodontally healthy and maintenance subjects. J Periodontol 79:784-94
Bogren, Anna; Teles, Ricardo P; Torresyap, Gay et al. (2008) Long-term effect of the combined use of powered toothbrush and triclosan dentifrice in periodontal maintenance patients. J Clin Periodontol 35:157-64
Bogren, Anna; Teles, Ricardo P; Torresyap, Gay et al. (2007) Clinical and microbiologic changes associated with the combined use of a powered toothbrush and a triclosan/copolymer dentifrice: a 3-year prospective study. J Periodontol 78:1708-17

Showing the most recent 10 out of 36 publications