Abstract

The purpose of the patient acquisition core is to create a patient data base for recruitment of study subjects for the program project. All projects of the Program Project, with the exception of the chemical synthesis project (Project 4), will require patient material for study. This core will take advantage of the existing clinical research center at Boston University to recruit subjects for study utilizing the demographic database and the established patient pool.
The specific aims of this core are to: 1. Recruit, categorize (diagnose), and collect basic demographic and clinical data from periodontitis patients. 2. After obtaining informed consent, to collect appropriate blood and gingival crevicular fluid samples as required by the respective projects of the Program Project. 3. Attend to the treatments needs of the recruited subjects, with the intention of collecting post-treatment samples for further analysis in the respective projects of the Program Project.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Research Program Projects (P01)
Project #
5P01DE013499-02
Application #
6438184
Study Section
Special Emphasis Panel (ZDE1)
Project Start
2000-04-01
Project End
2005-03-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2001
Total Cost
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Hirota, Simon A; Ng, Jeffrey; Lueng, Alan et al. (2011) NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis. Inflamm Bowel Dis 17:1359-72
Campbell, Eric L; MacManus, Christopher F; Kominsky, Douglas J et al. (2010) Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification. Proc Natl Acad Sci U S A 107:14298-303
Hirota, Simon A; Fines, Kyla; Ng, Jeffrey et al. (2010) Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury. Gastroenterology 139:259-69.e3
Keely, Simon; Glover, Louise E; MacManus, Christopher F et al. (2009) Selective induction of integrin beta1 by hypoxia-inducible factor: implications for wound healing. FASEB J 23:1338-46
Petasis, Nicos A; Butkevich, Alexey (2009) Synthesis of 2H-chromenes and 1,2-dihydroquinolines from aryl aldehydes, amines, and alkenylboron compounds. J Organomet Chem 694:1747-1753
Zemans, Rachel L; Colgan, Sean P; Downey, Gregory P (2009) Transepithelial migration of neutrophils: mechanisms and implications for acute lung injury. Am J Respir Cell Mol Biol 40:519-35
Eltzschig, Holger K; Macmanus, Christopher F; Colgan, Sean P (2008) Neutrophils as sources of extracellular nucleotides: functional consequences at the vascular interface. Trends Cardiovasc Med 18:103-7
Robinson, Andreas; Keely, Simon; Karhausen, Jorn et al. (2008) Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. Gastroenterology 134:145-55
Hong, Song; Lu, Yan; Yang, Rong et al. (2007) Resolvin D1, protectin D1, and related docosahexaenoic acid-derived products: Analysis via electrospray/low energy tandem mass spectrometry based on spectra and fragmentation mechanisms. J Am Soc Mass Spectrom 18:128-44
Campbell, Eric L; Louis, Nancy A; Tomassetti, Sarah E et al. (2007) Resolvin E1 promotes mucosal surface clearance of neutrophils: a new paradigm for inflammatory resolution. FASEB J 21:3162-70

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