The Tissue Bank and Pathology Core will have several functions that directly support the research investigators in this program project. Collection, storage, and cataloging of biopsies and surgical tissue specimens from oral cancers and precancers will be an essential goal; this will include the handling of specimens from animal models. Research investigators on the four major projects and the pilot projects will be provided frozen and paraffin-embedded tissue sections from oral cancerous and precancerous lesions as needed. A substantial numb3er (>3000) of archived and frozen biopsy specimens already have been formally organized as part of existing tissue bank for the UCSF Oral Cancer Research Center. Specimen information has been stored in an Access database. This database will be maintained to manage all data related to patients and clinical samples. Within the Tissue Bank, diagnostic groups include hyperplasia, hyperkeratosis, dysplasia, carcinoma in situs, verrucous carcinoma, and invasive squamous cell carcinoma, and invasive squamous cell carcinomas, and include several cohorts of SCC that are of biologic, etiologic, and/or pathogenetic significance, such as patients who have serial biopsies from a single oral region, patients in age group <35 years, and patients with oral dysplasias that progressed to SCC and others in which the dysplasia did not transform to SCC. New fresh and fixed specimens will be received from oral and surgical pathology with the assistance of personnel in the UCSF Cancer Center. Implementation of a universal surgical consent form will allow us to link fresh surgical specimens with patients through either medical chart review or the UCSF Cancer Registry. The Stomatology Clinical Center will continue to be valuable source of unfixed precancerous lesions. Outcome information on archived surgical specimens will continue to be added to the database through the cooperation of the UCSF Cancer Registry. Technical and consultative services in biostatistics, histopathology and immunohistochemistry will be provided to all investigators.
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| Dang, Dongmin; Atakilit, Amha; Ramos, Daniel M (2008) EMMPRIN modulates migration and deposition of TN-C in oral squamous carcinoma. Anticancer Res 28:2049-54 |
| Haga, Takeshi; Uchide, Noboru; Tugizov, Sharof et al. (2008) Role of E-cadherin in the induction of apoptosis of HPV16-positive CaSki cervical cancer cells during multicellular tumor spheroid formation. Apoptosis 13:97-108 |
| Shiboski, Caroline H; Schmidt, Brian L; Jordan, Richard C K (2007) Racial disparity in stage at diagnosis and survival among adults with oral cancer in the US. Community Dent Oral Epidemiol 35:233-40 |
| Schmidt, Brian L; Pickering, Victoria; Liu, Stanley et al. (2007) Peripheral endothelin A receptor antagonism attenuates carcinoma-induced pain. Eur J Pain 11:406-14 |
| Pickering, Victoria; Jordan, Richard C K; Schmidt, Brian L (2007) Elevated salivary endothelin levels in oral cancer patients--a pilot study. Oral Oncol 43:37-41 |
| Dang, Dongmin; Bamburg, James R; Ramos, Daniel M (2006) Alphavbeta3 integrin and cofilin modulate K1735 melanoma cell invasion. Exp Cell Res 312:468-77 |
| Tugizov, Sharof; Berline, Jennifer; Herrera, Rossana et al. (2005) Inhibition of human papillomavirus type 16 E7 phosphorylation by the S100 MRP-8/14 protein complex. J Virol 79:1099-112 |
| Connelly, Stephen T; Macabeo-Ong, Maricris; Dekker, Nusi et al. (2005) Increased nitric oxide levels and iNOS over-expression in oral squamous cell carcinoma. Oral Oncol 41:261-7 |
| Kramer, Randall H; Shen, Xiaodong; Zhou, Hua (2005) Tumor cell invasion and survival in head and neck cancer. Cancer Metastasis Rev 24:35-45 |
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