Abstract

The broad objective of this research program is to gain understanding of the nature of diabetes mellitus in humans, particularly with regard to etiology and to mechanisms of pathological, physiological, and biochemical changes. The proposed approach to the pathobiology of diabetes mellitus focuses on four major interrelated areas: 1. insulin secretion; 2. insulin action; 3. the pathogenesis of different forms of diabetes; and 4. the pathogenesis of atherosclerosis in diabetes. Projects are proposed to study the role of prostaglandins in pancreatic islet function, regulation of prostaglandin-E receptors in pancreatic islets and adipocytes, studies of oscillatory secretion of somatostatin, mechanism of action of insulin on cell membranes, regulation of the function of lysosomes in diabetes, factors influencing the pathogenesis of insulin-dependent diabetes, obesity and adipose tissue lipoprotein lipase activity, particularly in relation to non-insulin dependent diabetes, the interactions of human arterial cells with lipoproteins, and the regulation of arterial cell metabolism in diabetes, and a common project involving several investigators focused on lipoprotein abnormalities in diabetes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK002456-30
Application #
3095103
Study Section
(SRC)
Project Start
1976-09-01
Project End
1991-08-31
Budget Start
1988-09-01
Budget End
1989-08-31
Support Year
30
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Hutchins, Patrick M; Heinecke, Jay W (2015) Cholesterol efflux capacity, macrophage reverse cholesterol transport and cardioprotective HDL. Curr Opin Lipidol 26:388-93
Vaisar, Tomáš; Tang, Chongren; Babenko, Ilona et al. (2015) Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity. J Lipid Res 56:1519-30
Hutchins, Patrick M; Ronsein, Graziella E; Monette, Jeffrey S et al. (2014) Quantification of HDL particle concentration by calibrated ion mobility analysis. Clin Chem 60:1393-401
Umemoto, Tomio; Han, Chang Yeop; Mitra, Poulami et al. (2013) Apolipoprotein AI and high-density lipoprotein have anti-inflammatory effects on adipocytes via cholesterol transporters: ATP-binding cassette A-1, ATP-binding cassette G-1, and scavenger receptor B-1. Circ Res 112:1345-54
Purnell, Jonathan Q; Zinman, Bernard; Brunzell, John D et al. (2013) The effect of excess weight gain with intensive diabetes mellitus treatment on cardiovascular disease risk factors and atherosclerosis in type 1 diabetes mellitus: results from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interven Circulation 127:180-7
Liu, Yuhua; Tang, Chongren (2012) Regulation of ABCA1 functions by signaling pathways. Biochim Biophys Acta 1821:522-9
de Boer, Ian H; Sachs, Michael C; Cleary, Patricia A et al. (2012) Circulating vitamin D metabolites and kidney disease in type 1 diabetes. J Clin Endocrinol Metab 97:4780-8
Hoofnagle, Andrew N; Wu, Mingyuan; Gosmanova, Albina K et al. (2010) Low clusterin levels in high-density lipoprotein associate with insulin resistance, obesity, and dyslipoproteinemia. Arterioscler Thromb Vasc Biol 30:2528-34
Tang, Chongren; Kanter, Jenny E; Bornfeldt, Karin E et al. (2010) Diabetes reduces the cholesterol exporter ABCA1 in mouse macrophages and kidneys. J Lipid Res 51:1719-28
Vaisar, Tomás; Kassim, Sean Y; Gomez, Ivan G et al. (2009) MMP-9 sheds the beta2 integrin subunit (CD18) from macrophages. Mol Cell Proteomics 8:1044-60

Showing the most recent 10 out of 24 publications