Abstract

The local DCCT/EDIC Cohort Core (Core B1) is designed to make available samples (plasma, lipoproteins and urine) from carefully characterized subjects being followed in the Seattle cohort of the EDIC for use by investigators in the individual projects. The Arterial Tissue and Applied Pathology Core (Core B2) is designed to enhance the scientific objectives and cost-effectiveness of the Program Project in two ways: 1) by providing a centralized repository for diabetic and non-diabetic arterial tissue to be used in tissue-based analyses and 2) by performing specialized tissue- based analyses, including histologic, immunohistochemical (IHC), and in situ hybridization (ISH) studies, as required by the individual projects. Centralizing and standardizing tissue collection will ensure uniformity collection and preservation of samples. Performing histologic and not compel individual projects to develop technical expertise in these areas. Further, carrying out these studies at a single site will allow the results to be made available to each project in a way that facilitates Project interaction

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK002456-41
Application #
6300951
Study Section
Project Start
1999-12-01
Project End
2000-11-30
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
41
Fiscal Year
2000
Total Cost
$181,027
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Hutchins, Patrick M; Heinecke, Jay W (2015) Cholesterol efflux capacity, macrophage reverse cholesterol transport and cardioprotective HDL. Curr Opin Lipidol 26:388-93
Vaisar, Tomáš; Tang, Chongren; Babenko, Ilona et al. (2015) Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity. J Lipid Res 56:1519-30
Hutchins, Patrick M; Ronsein, Graziella E; Monette, Jeffrey S et al. (2014) Quantification of HDL particle concentration by calibrated ion mobility analysis. Clin Chem 60:1393-401
Purnell, Jonathan Q; Zinman, Bernard; Brunzell, John D et al. (2013) The effect of excess weight gain with intensive diabetes mellitus treatment on cardiovascular disease risk factors and atherosclerosis in type 1 diabetes mellitus: results from the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interven Circulation 127:180-7
Umemoto, Tomio; Han, Chang Yeop; Mitra, Poulami et al. (2013) Apolipoprotein AI and high-density lipoprotein have anti-inflammatory effects on adipocytes via cholesterol transporters: ATP-binding cassette A-1, ATP-binding cassette G-1, and scavenger receptor B-1. Circ Res 112:1345-54
Liu, Yuhua; Tang, Chongren (2012) Regulation of ABCA1 functions by signaling pathways. Biochim Biophys Acta 1821:522-9
de Boer, Ian H; Sachs, Michael C; Cleary, Patricia A et al. (2012) Circulating vitamin D metabolites and kidney disease in type 1 diabetes. J Clin Endocrinol Metab 97:4780-8
Hoofnagle, Andrew N; Wu, Mingyuan; Gosmanova, Albina K et al. (2010) Low clusterin levels in high-density lipoprotein associate with insulin resistance, obesity, and dyslipoproteinemia. Arterioscler Thromb Vasc Biol 30:2528-34
Tang, Chongren; Kanter, Jenny E; Bornfeldt, Karin E et al. (2010) Diabetes reduces the cholesterol exporter ABCA1 in mouse macrophages and kidneys. J Lipid Res 51:1719-28
Vaisar, Tomás; Kassim, Sean Y; Gomez, Ivan G et al. (2009) MMP-9 sheds the beta2 integrin subunit (CD18) from macrophages. Mol Cell Proteomics 8:1044-60

Showing the most recent 10 out of 24 publications