Abstract

This is an application for competitive renewal of a program project grant which has been active for 29 years. It involves many investigators and many different projects all relating to the improve of the results of organ transplantation. The basic overall OBJECTIVES of this grant have been to: (A) Analyze and isolate the clinical problems involved in organ transplantation and precisely document clinical laboratory correlations. (B) Organize clinical trials based on available data to solve clinical problems. (C) Generate experimental approaches to help solve clinical problems. Within these objectives, all projects are organized into two essential AIMS:
AIM 1 : TO PREVENT ORGAN DESTRUCTION. This includes not only immunological manipulations designed to prevent rejection but also those designed to prevent non-immunologic graft loss, to prolong patient survival, and to modify or control drug toxicity and recurrent disease.
AIM 2 : TO MAXIMIZE REHABILITATION. The focus here is on minimizing complications and maximizing compliance with the immunosuppressive regimen. Within this framework, the current applications include projects addressing late mortality (1 project), chronic graft loss (4 projects), defining risk factors (1 project), and decreasing morbidity 5 projects. The 2 Cores--Clinical and Administrative-support all projects.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
3P01DK013083-33S1
Application #
6502227
Study Section
Special Emphasis Panel (ZDK1 (M1))
Program Officer
Flessner, Michael Francis
Project Start
1992-09-30
Project End
2002-11-30
Budget Start
2000-12-01
Budget End
2001-11-30
Support Year
33
Fiscal Year
2001
Total Cost
$82,500
Indirect Cost

  Institution

Name
University of Minnesota Twin Cities
Department
Surgery
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Berglund, Danielle M; Zhang, Lei; Matas, Arthur J et al. (2018) Measured Glomerular Filtration Rate After Kidney Donation: No Evidence of Accelerated Decay. Transplantation 102:1756-1761
Matas, Arthur J; Vock, David M; Ibrahim, Hassan N (2018) GFR ?25 years postdonation in living kidney donors with (vs. without) a first-degree relative with ESRD. Am J Transplant 18:625-631
Sanchez, Otto A; Ferrara, Laine K; Rein, Sarah et al. (2018) Hypertension after kidney donation: Incidence, predictors, and correlates. Am J Transplant 18:2534-2543
Serrano, Oscar Kenneth; Kandaswamy, Raja; Gillingham, Kristen et al. (2017) Rapid Discontinuation of Prednisone in Kidney Transplant Recipients: 15-Year Outcomes From the University of Minnesota. Transplantation 101:2590-2598
Ibrahim, H N; Berglund, D M; Jackson, S et al. (2017) Renal Consequences of Diabetes After Kidney Donation. Am J Transplant 17:3141-3148
Gross, Cynthia R; Reilly-Spong, Maryanne; Park, Taehwan et al. (2017) Telephone-adapted Mindfulness-based Stress Reduction (tMBSR) for patients awaiting kidney transplantation. Contemp Clin Trials 57:37-43
Kizilbash, Sarah J; Rheault, Michelle N; Bangdiwala, Ananta et al. (2017) Infection rates in tacrolimus versus cyclosporine-treated pediatric kidney transplant recipients on a rapid discontinuation of prednisone protocol: 1-year analysis. Pediatr Transplant 21:
Verghese, P S; Schmeling, D O; Filtz, E A et al. (2017) The impact of recipient BKV shedding before transplant on BKV viruria, DNAemia, and nephropathy post-transplant: A prospective study. Pediatr Transplant 21:
Ibrahim, Hassan N; Foley, Robert N; Reule, Scott A et al. (2016) Renal Function Profile in White Kidney Donors: The First 4 Decades. J Am Soc Nephrol 27:2885-93
Verghese, Priya; Gillingham, Kristen; Matas, Arthur et al. (2016) Post-transplant blood transfusions and pediatric renal allograft outcomes. Pediatr Transplant 20:939-945

Showing the most recent 10 out of 356 publications