For the patient with a successful organ transplant, the musculoskeletal complications of non-specific bone pain and osteonecrosis all too frequently arise within the first several years after transplantation and are debilitating just as the patient is enjoying a new lease on life. The long term objectives of this proposal are to study 3 issues central to the musculoskeletal problems encountered by transplant patients. (1) Nonspecific bone pain (NSBP) is a newly recognized entity which is poorly understood and is secondary to immunosuppression. It may be related to early stage osteonecrosis. This proposal will prospectively study the natural history, improve the diagnostic criteria and test calcium channel blockers in the treatment of NSBP using a double blind, randomized study as well as explore a potential relationship to osteonecrosis. (2) Osteonecrosis of the femoral head (ONFH) is a dreaded complication of immunosuppression as it is crippling and there is no treatment which can reliably salvage the hip joint. A reversible stage of osteonecrosis has recently been described. This proposal will use MRI to prospectively study whether or not a reversible stage exists and the prognostic factors which may predict which patients will develop progressive collapse f the femoral head. (3) At present, surgical procedures to preserve the hip joint are unreliable in their success. This proposal will use functional and clinical outcomes measurement to study a new procedure, core decompression with methylmethacrylate cement packing, designed to prevent or forestall the development of end-stage arthritis in patients with either pre- femoral head collapse ONFH (single blind, randomized, prospective study), or post-femoral head collapse ONFH (single blind, randomized, prospective study), or post-femoral head collapse ONFH (prospective study).

Project Start
2000-12-01
Project End
2001-11-30
Budget Start
Budget End
Support Year
33
Fiscal Year
2001
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Berglund, Danielle M; Zhang, Lei; Matas, Arthur J et al. (2018) Measured Glomerular Filtration Rate After Kidney Donation: No Evidence of Accelerated Decay. Transplantation 102:1756-1761
Matas, Arthur J; Vock, David M; Ibrahim, Hassan N (2018) GFR ?25 years postdonation in living kidney donors with (vs. without) a first-degree relative with ESRD. Am J Transplant 18:625-631
Sanchez, Otto A; Ferrara, Laine K; Rein, Sarah et al. (2018) Hypertension after kidney donation: Incidence, predictors, and correlates. Am J Transplant 18:2534-2543
Kizilbash, Sarah J; Rheault, Michelle N; Bangdiwala, Ananta et al. (2017) Infection rates in tacrolimus versus cyclosporine-treated pediatric kidney transplant recipients on a rapid discontinuation of prednisone protocol: 1-year analysis. Pediatr Transplant 21:
Verghese, P S; Schmeling, D O; Filtz, E A et al. (2017) The impact of recipient BKV shedding before transplant on BKV viruria, DNAemia, and nephropathy post-transplant: A prospective study. Pediatr Transplant 21:
Serrano, Oscar Kenneth; Kandaswamy, Raja; Gillingham, Kristen et al. (2017) Rapid Discontinuation of Prednisone in Kidney Transplant Recipients: 15-Year Outcomes From the University of Minnesota. Transplantation 101:2590-2598
Ibrahim, H N; Berglund, D M; Jackson, S et al. (2017) Renal Consequences of Diabetes After Kidney Donation. Am J Transplant 17:3141-3148
Gross, Cynthia R; Reilly-Spong, Maryanne; Park, Taehwan et al. (2017) Telephone-adapted Mindfulness-based Stress Reduction (tMBSR) for patients awaiting kidney transplantation. Contemp Clin Trials 57:37-43
Ibrahim, Hassan N; Foley, Robert N; Reule, Scott A et al. (2016) Renal Function Profile in White Kidney Donors: The First 4 Decades. J Am Soc Nephrol 27:2885-93
Verghese, Priya; Gillingham, Kristen; Matas, Arthur et al. (2016) Post-transplant blood transfusions and pediatric renal allograft outcomes. Pediatr Transplant 20:939-945

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