Abstract

This is an application for competitive renewal of a Program Project Grant that has been active for 39 years. It involves many investigators and many different projects, all relating to the improvement of the results of solid organ transplantation. The basic overall OBJECTIVES of this grant are to: A. isolate and analyze clinical problems in solid organ transplantation and precisely document clinical/laboratory correlations; B. organize clinical trials and experimental approaches based on available data to help solve clinical problems. Within these objectives, all projects on the current grant are organized into two specific AIMS: 1. To prevent organ destruction. This includes not only immunologic manipulations designed to prevent rejection and immunologic graft loss, but also those designed to prevent nonimmunologic graft loss, to prolong recipient survival, and to modify or control drug toxicity and recurrent disease. 2. To maximize rehabilitation. The focus here is on minimizing complications and maximizing quality of life.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK013083-43
Application #
8326694
Study Section
Special Emphasis Panel (ZDK1-GRB-R (J1))
Program Officer
Flessner, Michael Francis
Project Start
1998-02-21
Project End
2014-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
43
Fiscal Year
2012
Total Cost
$1,286,034
Indirect Cost
$430,073

  Institution

Name
University of Minnesota Twin Cities
Department
Surgery
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455

  Publications

Berglund, Danielle M; Zhang, Lei; Matas, Arthur J et al. (2018) Measured Glomerular Filtration Rate After Kidney Donation: No Evidence of Accelerated Decay. Transplantation 102:1756-1761
Matas, Arthur J; Vock, David M; Ibrahim, Hassan N (2018) GFR ?25 years postdonation in living kidney donors with (vs. without) a first-degree relative with ESRD. Am J Transplant 18:625-631
Sanchez, Otto A; Ferrara, Laine K; Rein, Sarah et al. (2018) Hypertension after kidney donation: Incidence, predictors, and correlates. Am J Transplant 18:2534-2543
Kizilbash, Sarah J; Rheault, Michelle N; Bangdiwala, Ananta et al. (2017) Infection rates in tacrolimus versus cyclosporine-treated pediatric kidney transplant recipients on a rapid discontinuation of prednisone protocol: 1-year analysis. Pediatr Transplant 21:
Verghese, P S; Schmeling, D O; Filtz, E A et al. (2017) The impact of recipient BKV shedding before transplant on BKV viruria, DNAemia, and nephropathy post-transplant: A prospective study. Pediatr Transplant 21:
Serrano, Oscar Kenneth; Kandaswamy, Raja; Gillingham, Kristen et al. (2017) Rapid Discontinuation of Prednisone in Kidney Transplant Recipients: 15-Year Outcomes From the University of Minnesota. Transplantation 101:2590-2598
Ibrahim, H N; Berglund, D M; Jackson, S et al. (2017) Renal Consequences of Diabetes After Kidney Donation. Am J Transplant 17:3141-3148
Gross, Cynthia R; Reilly-Spong, Maryanne; Park, Taehwan et al. (2017) Telephone-adapted Mindfulness-based Stress Reduction (tMBSR) for patients awaiting kidney transplantation. Contemp Clin Trials 57:37-43
Ibrahim, Hassan N; Foley, Robert N; Reule, Scott A et al. (2016) Renal Function Profile in White Kidney Donors: The First 4 Decades. J Am Soc Nephrol 27:2885-93
Verghese, Priya; Gillingham, Kristen; Matas, Arthur et al. (2016) Post-transplant blood transfusions and pediatric renal allograft outcomes. Pediatr Transplant 20:939-945

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