Abstract

The purpose of this proposal is to incorporate the research activities and funding of members of the Division of Nephrology of The University of Texas Health Science Center and other investigators with closely related interests into one program. The general topics are: I. Isolated Perfused Glomerulus II. Control of Urinary Sodium Excretion III. Pathophysiology of Acute Renal Failure IV. Tubular Acidification: Tubular Protein Transport V. Cell Culture Studies VI. Effect of Potassium Depletion on Renal Tubular Function VII. Membrane Pathology in Renal Cell Injury

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK017387-18
Application #
3095159
Study Section
Special Emphasis Panel (SRC)
Project Start
1976-05-01
Project End
1992-06-30
Budget Start
1990-07-01
Budget End
1992-06-30
Support Year
18
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
University of Texas Health Science Center San Antonio
Department
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229

  Publications

Kobayashi, S; Clemmons, D R; Nogami, H et al. (1995) Tubular hypertrophy due to work load induced by furosemide is associated with increases of IGF-1 and IGFBP-1. Kidney Int 47:818-28
Venkatachalam, M A; Weinberg, J M (1994) Mechanisms of cell injury in ATP-depleted proximal tubules. Role of glycine, calcium, and polyphosphoinositides. Nephrol Dial Transplant 9 Suppl 4:15-21
Garza-Quintero, R; Weinberg, J M; Ortega-Lopez, J et al. (1993) Conservation of structure in ATP-depleted proximal tubules: role of calcium, polyphosphoinositides, and glycine. Am J Physiol 265:F605-23
Ayo, S H; Kreisberg, J I (1991) Heparin increases hillock formation in mesangial cell cultures. J Am Soc Nephrol 2:1153-7
Ayo, S H; Radnik, R A; Glass 2nd, W F et al. (1991) Increased extracellular matrix synthesis and mRNA in mesangial cells grown in high-glucose medium. Am J Physiol 260:F185-91
Kobayashi, S; Clemmons, D R; Venkatachalam, M A (1991) Colocalization of insulin-like growth factor-binding protein with insulin-like growth factor I. Am J Physiol 261:F22-8
Kunau Jr, R T; Walker, K A (1990) Distal tubular acidification in the remnant kidney. Am J Physiol 258:F69-74
Bock, H A; Hermle, M; Fiallo, A et al. (1990) Measurement of renin secretion in single perfused rabbit glomeruli. Am J Physiol 258:F1460-5
Stein, J H (1990) Regulation of the renal circulation. Kidney Int 38:571-6
McCall, D; Fried, T A (1990) Effect of atriopeptin II on Ca influx, contractile behavior and cyclic nucleotide content of cultured neonatal rat myocardial cells. J Mol Cell Cardiol 22:201-12

Showing the most recent 10 out of 14 publications