The overall goal of this program project continues to be the development of a rational treatment program for nephrolithiasis, in which the chosen treatment corrects underlying derangements and prevent new stone formation without causing complications. Much progress has been made: (a) a diagnostic protocol capable of elucidating the cause of stone disease in more than 95% of patients has been developed, (b) the work under this program project resulted in development of sodium cellulose phosphate, potassium citrate and MPG. In this renewal, further pathophysiologic and therapeutic explorations are planned: (a) the importance of 1,25-(OH)2D in absorptive hypercalciuria will be examined by receptor binding and RFP, as well as by antagonism of 1,25-(OH)2D action by 25,26-(OH)2D; (b) the renal contribution of hypocitraturia will be evaluated using rat tubular microperfusion as well as by measurement of renal tissue pH in vivo; (c) the intestinal contribution to hypocitraturia will be explored from the correlation of net gastrointestinal absorption of alkali with urinary citrate, and from direct measurement of intestinal citrate absorption; (d) adverse physiological consequences of lithotripsy will be critically assessed; (e) extra-renal sequelae of long-term medical treatments will be quantitated; and (f) therapeutic potential of potassium-magnesium citrate and 25,26-(OH)2D will be investigated.
| Xu, Li Hao Richie; Maalouf, Naim M (2017) Effect of acute hyperinsulinemia on magnesium homeostasis in humans. Diabetes Metab Res Rev 33: |
| Xu, Li Hao Richie; Adams-Huet, Beverley; Poindexter, John R et al. (2017) Temporal Changes in Kidney Stone Composition and in Risk Factors Predisposing to Stone Formation. J Urol 197:1465-1471 |
| Sakhaee, Khashayar; Poindexter, John; Aguirre, Crystal (2016) The effects of bariatric surgery on bone and nephrolithiasis. Bone 84:1-8 |
| Hu, Ming Chang; Shi, Mingjun; Cho, Han Jun et al. (2015) Klotho and phosphate are modulators of pathologic uremic cardiac remodeling. J Am Soc Nephrol 26:1290-302 |
| Hajibeigi, Asghar; Dioum, Elhadji M; Guo, Jianfei et al. (2015) Identification of novel regulatory NFAT and TFII-I binding elements in the calbindin-D28k promoter in response to serum deprivation. Biochem Biophys Res Commun 465:414-420 |
| Yoon, Vivienne; Adams-Huet, Beverley; Sakhaee, Khashayar et al. (2013) Hyperinsulinemia and urinary calcium excretion in calcium stone formers with idiopathic hypercalciuria. J Clin Endocrinol Metab 98:2589-94 |
| Capolongo, Giovanna; Abul-Ezz, Sameh; Moe, Orson W et al. (2012) Subclinical celiac disease and crystal-induced kidney disease following kidney transplant. Am J Kidney Dis 60:662-7 |
| Cameron, MaryAnn; Maalouf, Naim M; Poindexter, John et al. (2012) The diurnal variation in urine acidification differs between normal individuals and uric acid stone formers. Kidney Int 81:1123-30 |
| Sakhaee, Khashayar; Capolongo, Giovanna; Maalouf, Naim M et al. (2012) Metabolic syndrome and the risk of calcium stones. Nephrol Dial Transplant 27:3201-9 |
| Nguyen, Trang Q; Maalouf, Naim M; Sakhaee, Khashayar et al. (2011) Comparison of insulin action on glucose versus potassium uptake in humans. Clin J Am Soc Nephrol 6:1533-9 |
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