Abstract

Public Health Relevance

Shigella is a major cause of diarrhea, dysentery, and morbidity worldwide. S. flexneri is also a CDC/NIAID Category B priority pathogen that causes disease by invading and spreading through the colonic mucosa. The goal of this proposal is to understand the molecular mechanisms by which S. flexneri invades the colonic epithelium and subsequently triggers/controls the directed movement of PMN across the epithelial surface so that novel targets for therapeutic intervention in inflammatory Shigella infection can be identified.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
2P01DK033506-26A1
Application #
8262478
Study Section
Special Emphasis Panel (ZDK1-GRB-8 (O1))
Project Start
Project End
Budget Start
2011-09-23
Budget End
2012-08-31
Support Year
26
Fiscal Year
2011
Total Cost
$292,892
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Senger, Stefania; Ingano, Laura; Freire, Rachel et al. (2018) Human Fetal-Derived Enterospheres Provide Insights on Intestinal Development and a Novel Model to Study Necrotizing Enterocolitis (NEC). Cell Mol Gastroenterol Hepatol 5:549-568
Henström, Maria; Diekmann, Lena; Bonfiglio, Ferdinando et al. (2018) Functional variants in the sucrase-isomaltase gene associate with increased risk of irritable bowel syndrome. Gut 67:263-270
Guo, Shuangshuang; Gillingham, Tyler; Guo, Yuming et al. (2017) Secretions of Bifidobacterium infantis and Lactobacillus acidophilus Protect Intestinal Epithelial Barrier Function. J Pediatr Gastroenterol Nutr 64:404-412
Walker, W Allan (2017) The importance of appropriate initial bacterial colonization of the intestine in newborn, child, and adult health. Pediatr Res 82:387-395
Mercado-Lubo, Regino; Zhang, Yuanwei; Zhao, Liang et al. (2016) A Salmonella nanoparticle mimic overcomes multidrug resistance in tumours. Nat Commun 7:12225
Saslowsky, David E; Thiagarajah, Jay R; McCormick, Beth A et al. (2016) Microbial sphingomyelinase induces RhoA-mediated reorganization of the apical brush border membrane and is protective against invasion. Mol Biol Cell 27:1120-30
Rautava, Samuli; Walker, W Allan; Lu, Lei (2016) Hydrocortisone-induced anti-inflammatory effects in immature human enterocytes depend on the timing of exposure. Am J Physiol Gastrointest Liver Physiol 310:G920-9
Giannogonas, Panagiotis; Apostolou, Athanasia; Manousopoulou, Antigoni et al. (2016) Identification of a novel interaction between corticotropin releasing hormone (Crh) and macroautophagy. Sci Rep 6:23342
Hoffman, Jill M; Baritaki, Stavroula; Ruiz, Jonathan J et al. (2016) Corticotropin-Releasing Hormone Receptor 2 Signaling Promotes Mucosal Repair Responses after Colitis. Am J Pathol 186:134-44
Meng, Di; Zhu, Weishu; Ganguli, Kriston et al. (2016) Anti-inflammatory effects of Bifidobacterium longum subsp infantis secretions on fetal human enterocytes are mediated by TLR-4 receptors. Am J Physiol Gastrointest Liver Physiol 311:G744-G753

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