Specific differentiated cell types in culture will be developed and exploited to study the normal physiology and metabolic disorders of parent tissues. The nutritive, hormonal and extracellular matrix requirements for growth and function of several differentiated cell types have been or will be optimized. Bioeffectors, receptors, transducers and gene products will be purified and characterized by techniques of protein chemistry and molecular biology. Immunochemical and cDNA probes will be developed to study regulation of cell growth and specific gene products by hormones. Our basic premise is that factors discovered in culture that affect growth, function and differentiation are hormones involved in tissue physiology. The elucidation of these factors, their physiologic action and mechanism of action have practical importance in the management of metabolic disorders. The program consists of five projects devoted to these problems as well as a protein chemistry and molecular biology core support laboratories.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK038639-04
Application #
3095504
Study Section
Diabetes, Endocrinology and Metabolic Diseases B Subcommittee (DDK)
Project Start
1988-03-01
Project End
1993-02-28
Budget Start
1991-03-01
Budget End
1992-02-29
Support Year
4
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Adirondack Biomedical Research Institute
Department
Type
DUNS #
City
Lake Placid
State
NY
Country
United States
Zip Code
12946
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