Abstract

The Barbara Davis Center EPICS C cytofluorograph will be used for all the cytofluorographic analyses proposed within the program project. It is currently used for one- and two-color immunofluorescence analyses, two-channel sorting based on cell size and immunofluorescence, and DNA-labelling cell cycle analyses. Data processing (statistical analyses as well as graphic display) is currently being performed on the standard EPICS C computer with standard software.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
1P01DK040144-01
Application #
3918178
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Colorado Denver
Department
Type
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045

  Publications

Peterson, J D; Haskins, K (1996) Transfer of diabetes in the NOD-scid mouse by CD4 T-cell clones. Differential requirement for CD8 T-cells. Diabetes 45:328-36
Sellins, K S; Gold, D P; Bellgrau, D (1996) Resistance to tolerance induction in the diabetes-prone biobreeding rat as one manifestation of abnormal responses to superantigens. Diabetologia 39:28-36
Gold, D P; Shaikewitz, S T; Mueller, D et al. (1995) T cells from BB-DP rats show a unique cytokine mRNA profile associated with the IDDM1 susceptibility gene, Lyp. Autoimmunity 22:149-61
Peterson, J D; Pike, B; Dallas-Pedretti, A et al. (1995) Induction of diabetes with islet-specific T-cell clones is age dependent. Immunology 85:455-60
Bergman, B; Haskins, K (1994) Islet-specific T-cell clones from the NOD mouse respond to beta-granule antigen. Diabetes 43:197-203
Peterson, J D; Pike, B; McDuffie, M et al. (1994) Islet-specific T cell clones transfer diabetes to nonobese diabetic (NOD) F1 mice. J Immunol 153:2800-6
Bellgrau, D; Redd, J M; Sellins, K S (1994) Peculiar T-cell signaling does not preclude positive selection in the diabetes-prone BB rat. Diabetes 43:47-52
Shehadeh, N N; LaRosa, F; Lafferty, K J (1993) Altered cytokine activity in adjuvant inhibition of autoimmune diabetes. J Autoimmun 6:291-300
Lafferty, K J; Gill, R G (1993) The maintenance of self-tolerance. Immunol Cell Biol 71 ( Pt 3):209-14
Shehadeh, N N; Gill, R G; Lafferty, K J (1993) Mechanism of self-tolerance to endocrine tissue. Springer Semin Immunopathol 14:203-20

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