Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Wilson, Maria E; Scheel, David; German, Michael S (2003) Gene expression cascades in pancreatic development. Mech Dev 120:65-80
Sander, M; Sussel, L; Conners, J et al. (2000) Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas. Development 127:5533-40
Shi, Y; Kanaani, J; Menard-Rose, V et al. (2000) Increased expression of GAD65 and GABA in pancreatic beta-cells impairs first-phase insulin secretion. Am J Physiol Endocrinol Metab 279:E684-94
Sander, M; Paydar, S; Ericson, J et al. (2000) Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates. Genes Dev 14:2134-9
Roll, U; Turck, C W; Gitelman, S E et al. (2000) Peptide mapping and characterisation of glycation patterns of the glima 38 antigen recognised by autoantibodies in Type I diabetic patients. Diabetologia 43:598-608
Kanaani, J; Lissin, D; Kash, S F et al. (1999) The hydrophilic isoform of glutamate decarboxylase, GAD67, is targeted to membranes and nerve terminals independent of dimerization with the hydrophobic membrane-anchored isoform, GAD65. J Biol Chem 274:37200-9
Schwartz, H L; Chandonia, J M; Kash, S F et al. (1999) High-resolution autoreactive epitope mapping and structural modeling of the 65 kDa form of human glutamic acid decarboxylase. J Mol Biol 287:983-99
Smith, S B; Ee, H C; Conners, J R et al. (1999) Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development. Mol Cell Biol 19:8272-80
Bridgett, M; Cetkovic-Cvrlje, M; O'Rourke, R et al. (1998) Differential protection in two transgenic lines of NOD/Lt mice hyperexpressing the autoantigen GAD65 in pancreatic beta-cells. Diabetes 47:1848-56
Sander, M; Neubuser, A; Kalamaras, J et al. (1997) Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development. Genes Dev 11:1662-73

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