Abstract

The overall mission of the Protein Chemistry core is to provide the necessary equipment and technical support for 1) peptide synthesis, 2) microsequence analysis of proteins, and 3) measurement of protein- protein and protein-DNA interactions by means of plasmon resonance analysis and fluorescence polarization analysis. The core laboratory will further enhance scientific exchange between the four participating research groups and save a substantial amount of reseach effort and costs for each of the component labs.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK044239-08
Application #
6105489
Study Section
Project Start
1999-04-01
Project End
2000-03-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
8
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Oregon Health and Science University
Department
Type
DUNS #
009584210
City
Portland
State
OR
Country
United States
Zip Code
97239

  Publications

Zhang, Qinghong; Wang, Su-Yan; Fleuriel, Capucine et al. (2007) Metabolic regulation of SIRT1 transcription via a HIC1:CtBP corepressor complex. Proc Natl Acad Sci U S A 104:829-33
Soderling, Scott H; Guire, Eric S; Kaech, Stefanie et al. (2007) A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory. J Neurosci 27:355-65
Felmy, Felix (2007) Modulation of cargo release from dense core granules by size and actin network. Traffic 8:983-97
Zhang, Qinghong; Wang, Su-Yan; Nottke, Amanda C et al. (2006) Redox sensor CtBP mediates hypoxia-induced tumor cell migration. Proc Natl Acad Sci U S A 103:9029-33
Dodge-Kafka, Kimberly L; Langeberg, Lorene; Scott, John D (2006) Compartmentation of cyclic nucleotide signaling in the heart: the role of A-kinase anchoring proteins. Circ Res 98:993-1001
Wan, Lei; Almers, Wolfhard; Chen, Wenbiao (2005) Two ribeye genes in teleosts: the role of Ribeye in ribbon formation and bipolar cell development. J Neurosci 25:941-9
Pawson, Tony; Scott, John D (2005) Protein phosphorylation in signaling--50 years and counting. Trends Biochem Sci 30:286-90
Zhang, Qinghong; Nottke, Amanda; Goodman, Richard H (2005) Homeodomain-interacting protein kinase-2 mediates CtBP phosphorylation and degradation in UV-triggered apoptosis. Proc Natl Acad Sci U S A 102:2802-7
Taraska, Justin W; Almers, Wolfhard (2004) Bilayers merge even when exocytosis is transient. Proc Natl Acad Sci U S A 101:8780-5
Wayman, Gary A; Kaech, Stefanie; Grant, Wilmon F et al. (2004) Regulation of axonal extension and growth cone motility by calmodulin-dependent protein kinase I. J Neurosci 24:3786-94

Showing the most recent 10 out of 65 publications