Abstract

This Animal Model Core will be responsible for ordering mice, scheduling their use, performing the various manipulations required to induce experimental colitis, maintaining a barrier facility performing routine surveys to insure absence of any pathogens in the colony, and assist in the harvesting of tissues from such mice. Centralization of these functions in an Animal Model Core provides uniformity and quality control of mouse models being studied in the various projects, reduces cost because each project will not have to prepare and maintain their own animals, and conserve numbers of mice by ensuring maximal use of each one in the various projects. A centralized pathologic analysis, including scoring of colonic or intestinal inflammation, is performed for each project through this Core.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK044240-07S1
Application #
2845052
Study Section
Project Start
Project End
Budget Start
1996-10-01
Budget End
1997-09-30
Support Year
7
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of Alabama Birmingham
Department
Type
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294

  Publications

Jurisic, Giorgia; Sundberg, John P; Detmar, Michael (2013) Blockade of VEGF receptor-3 aggravates inflammatory bowel disease and lymphatic vessel enlargement. Inflamm Bowel Dis 19:1983-9
Luckey, C John; Weaver, Casey T (2012) Stem-cell-like qualities of immune memory; CD4+ T cells join the party. Cell Stem Cell 10:107-8
Jurisic, G; Sundberg, J P; Bleich, A et al. (2010) Quantitative lymphatic vessel trait analysis suggests Vcam1 as candidate modifier gene of inflammatory bowel disease. Genes Immun 11:219-31
Bleich, Andre; Büchler, Gwen; Beckwith, Jason et al. (2010) Cdcs1 a major colitis susceptibility locus in mice; subcongenic analysis reveals genetic complexity. Inflamm Bowel Dis 16:765-75
Maynard, Craig L; Weaver, Casey T (2008) Diversity in the contribution of interleukin-10 to T-cell-mediated immune regulation. Immunol Rev 226:219-33
Elson, Charles O; Cong, Yingzi; Weaver, Casey T et al. (2007) Monoclonal anti-interleukin 23 reverses active colitis in a T cell-mediated model in mice. Gastroenterology 132:2359-70
Duverger, Alexandra; Jackson, Raymond J; van Ginkel, Frederick W et al. (2006) Bacillus anthracis edema toxin acts as an adjuvant for mucosal immune responses to nasally administered vaccine antigens. J Immunol 176:1776-83
Elson, Charles O; Cong, Yingzi; Qi, Fengxia et al. (2006) Molecular approaches to the role of the microbiota in inflammatory bowel disease. Ann N Y Acad Sci 1072:39-51
Konrad, Astrid; Cong, Yingzi; Duck, Wayne et al. (2006) Tight mucosal compartmentation of the murine immune response to antigens of the enteric microbiota. Gastroenterology 130:2050-9
van Ginkel, Frederik W; Jackson, Raymond J; Yoshino, Naoto et al. (2005) Enterotoxin-based mucosal adjuvants alter antigen trafficking and induce inflammatory responses in the nasal tract. Infect Immun 73:6892-902

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