This Core has grown substantially and has been quite successful since its inception as part of the Program Project Grant DK49210. The Core expanded in 1997 to provides services and reagents to members of the Center for Molecular Studies in Digestive and Liver Disease P30DK50306. Within the past two years, Debra Silberg M.D., Ph.D., became the Director of the Core. With the growth of the Core and the addition of the financial support from DK50306, Gary Swain, Ph.D. was hired as the Technical Director. Both Drs. Silberg and Swain have been essential in expanding the scientific aspects of the Core by teaching techniques to the Core members and assisting in the development of protocols for new antibodies for immunohistochemistry. With the addition of two full time technicians, the Core has been able to provide quality services in a timely manner to the members of the Program Project with an overall increase in usage over the past year. The following description of the Core will outline the services provided, including a section that will focus on how each investigator will utilize the Morphology Core (Section 8). In addition, Morphologic data generated by each of the Principle Investigators will be presented as an example of the quality of work that can be expected (Section 9). An important aspect of this Core has been the interactions that have occurred among its members. The Morphology Core is located on the 6th floor of the Clinical Research Building, in rooms adjacent to Drs. Lazar, Stoffers, and Silberg?s laboratories and one floor above Dr. Kaestner?s laboratory and three floors above the laboratory of Dr. Birnbaum. Due to the close location of the Morphology Core, it has become a center for Principal Investigators, fellows and technicians to network while performing immunohistochemistry or using the imaging equipment. Collaborations have been built through these interactions, and we anticipate fostering future collaborations in this way.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Research Program Projects (P01)
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Special Emphasis Panel (ZDK1)
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University of Pennsylvania
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Juliana, Christine A; Yang, Juxiang; Cannon, Corey E et al. (2018) A PDX1-ATF transcriptional complex governs ? cell survival during stress. Mol Metab 17:39-48
Barnoud, Thibaut; Budina-Kolomets, Anna; Basu, Subhasree et al. (2018) Tailoring Chemotherapy for the African-Centric S47 Variant of TP53. Cancer Res 78:5694-5705
Kim, Yong Hoon; Marhon, Sajid A; Zhang, Yuxiang et al. (2018) Rev-erb? dynamically modulates chromatin looping to control circadian gene transcription. Science 359:1274-1277
Plikus, Maksim V; Guerrero-Juarez, Christian F; Ito, Mayumi et al. (2017) Regeneration of fat cells from myofibroblasts during wound healing. Science 355:748-752
Juliana, Christine A; Yang, Juxiang; Rozo, Andrea V et al. (2017) ATF5 regulates ?-cell survival during stress. Proc Natl Acad Sci U S A 114:1341-1346
Ediger, Benjamin N; Lim, Hee-Woong; Juliana, Christine et al. (2017) LIM domain-binding 1 maintains the terminally differentiated state of pancreatic ? cells. J Clin Invest 127:215-229
Jang, Jessica C; Li, Jiang; Gambini, Luca et al. (2017) Human resistin protects against endotoxic shock by blocking LPS-TLR4 interaction. Proc Natl Acad Sci U S A 114:E10399-E10408
Carr, Rotonya M; Dhir, Ravindra; Mahadev, Kalyankar et al. (2017) Perilipin Staining Distinguishes Between Steatosis and Nonalcoholic Steatohepatitis in Adults and Children. Clin Gastroenterol Hepatol 15:145-147
Park, Hyeong Kyu; Kwak, Mi Kyung; Kim, Hye Jeong et al. (2017) Linking resistin, inflammation, and cardiometabolic diseases. Korean J Intern Med 32:239-247
Ackermann, Amanda M; Zhang, Jia; Heller, Aryel et al. (2017) High-fidelity Glucagon-CreER mouse line generated by CRISPR-Cas9 assisted gene targeting. Mol Metab 6:236-244

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