Abstract

(Taken directly from the application) Objectives: To test bladder and renal infection by E. coli, P. mirabilis, or C. glabrata wild types or mutants, 2) to produce rabbit polyclonal antibodies against selected antigens, and 3) to assess host immune response to experimental UTI.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
3P01DK049720-08S1
Application #
6610332
Study Section
Special Emphasis Panel (ZDK1)
Project Start
2002-07-01
Project End
2003-06-30
Budget Start
Budget End
Support Year
8
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
University of Maryland Baltimore
Department
Type
DUNS #
003255213
City
Baltimore
State
MD
Country
United States
Zip Code
21201

  Publications

Buckles, Eric L; Luterbach, Courtney L; Wang, Xiaolin et al. (2015) Signature-tagged mutagenesis and co-infection studies demonstrate the importance of P fimbriae in a murine model of urinary tract infection. Pathog Dis 73:
Buckles, Eric L; Wang, Xiaolin; Lane, M Chelsea et al. (2009) Role of the K2 capsule in Escherichia coli urinary tract infection and serum resistance. J Infect Dis 199:1689-97
Lane, M Chelsea; Li, Xin; Pearson, Melanie M et al. (2009) Oxygen-limiting conditions enrich for fimbriate cells of uropathogenic Proteus mirabilis and Escherichia coli. J Bacteriol 191:1382-92
Zupancic, Margaret L; Frieman, Matthew; Smith, David et al. (2008) Glycan microarray analysis of Candida glabrata adhesin ligand specificity. Mol Microbiol 68:547-59
Jacobsen, Sandra M; Lane, Mary C; Harro, Jean M et al. (2008) The high-affinity phosphate transporter Pst is a virulence factor for Proteus mirabilis during complicated urinary tract infection. FEMS Immunol Med Microbiol 52:180-93
Ma, Biao; Pan, Shih-Jung; Zupancic, Margaret L et al. (2007) Assimilation of NAD(+) precursors in Candida glabrata. Mol Microbiol 66:14-25
Buckles, Eric L; Wang, Xiaolin; Lockatell, C Virginia et al. (2006) PhoU enhances the ability of extraintestinal pathogenic Escherichia coli strain CFT073 to colonize the murine urinary tract. Microbiology 152:153-60
Castano, Irene; Pan, Shih-Jung; Zupancic, Margaret et al. (2005) Telomere length control and transcriptional regulation of subtelomeric adhesins in Candida glabrata. Mol Microbiol 55:1246-58
Domergue, Renee; Castano, Irene; De Las Penas, Alejandro et al. (2005) Nicotinic acid limitation regulates silencing of Candida adhesins during UTI. Science 308:866-70
Jansen, Angela M; Lockatell, Virginia; Johnson, David E et al. (2004) Mannose-resistant Proteus-like fimbriae are produced by most Proteus mirabilis strains infecting the urinary tract, dictate the in vivo localization of bacteria, and contribute to biofilm formation. Infect Immun 72:7294-305

Showing the most recent 10 out of 31 publications