Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK050268-04
Application #
6138023
Study Section
Special Emphasis Panel (SRC (02))
Program Officer
Scherbenske, M James
Project Start
1997-01-01
Project End
2001-12-31
Budget Start
2000-01-01
Budget End
2000-12-31
Support Year
4
Fiscal Year
2000
Total Cost
$709,190
Indirect Cost
Name
Emory University
Department
Physiology
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Ketsawatsomkron, Pimonrat; Stepp, David W; Fulton, David J et al. (2010) Molecular mechanism of angiotensin II-induced insulin resistance in aortic vascular smooth muscle cells: roles of Protein Tyrosine Phosphatase-1B. Vascul Pharmacol 53:160-8
Banes-Berceli, Amy K L; Ketsawatsomkron, Pimonrat; Ogbi, Safia et al. (2007) Angiotensin II and endothelin-1 augment the vascular complications of diabetes via JAK2 activation. Am J Physiol Heart Circ Physiol 293:H1291-9
Banes-Berceli, Amy K; Shaw, Sean; Ma, Guochuan et al. (2006) Effect of simvastatin on high glucose- and angiotensin II-induced activation of the JAK/STAT pathway in mesangial cells. Am J Physiol Renal Physiol 291:F116-21
Marrero, Mario B; Banes-Berceli, Amy K; Stern, David M et al. (2006) Role of the JAK/STAT signaling pathway in diabetic nephropathy. Am J Physiol Renal Physiol 290:F762-8
Banes, Amy K L; Shaw, Sean M; Tawfik, Amany et al. (2005) Activation of the JAK/STAT pathway in vascular smooth muscle by serotonin. Am J Physiol Cell Physiol 288:C805-12
Tawfik, Amany; Jin, Liming; Banes-Berceli, Amy K L et al. (2005) Hyperglycemia and reactive oxygen species mediate apoptosis in aortic endothelial cells through Janus kinase 2. Vascul Pharmacol 43:320-6
Banes-Berceli, Amy K L; Ogobi, Safia; Tawfik, Amany et al. (2005) Endothelin-1 activation of JAK2 in vascular smooth muscle cells involves NAD(P)H oxidase-derived reactive oxygen species. Vascul Pharmacol 43:310-9
Eaton, Douglas C; Chen, Jane; Ramosevac, Semra et al. (2004) Regulation of Na+ channels in lung alveolar type II epithelial cells. Proc Am Thorac Soc 1:10-6
Marrero, Mario B; Papke, Roger L; Bhatti, Balwinder S et al. (2004) The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. J Pharmacol Exp Ther 309:16-27
Banes, Amy K; Shaw, Sean; Jenkins, John et al. (2004) Angiotensin II blockade prevents hyperglycemia-induced activation of JAK and STAT proteins in diabetic rat kidney glomeruli. Am J Physiol Renal Physiol 286:F653-9

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