Abstract

Core: This resource core will provide common reagents such as oligonucleotides, vectors for DNA transfer into mammalian cells and generation of knockouts, in addition to the DNA sequencing service. It will assist in the generation of the proposed knockout and transgenic mice, carry out animal breeding and maintenance of founders and provide expertise in the in vitro ES to macrophage differentiation, and in tissue processing and analysis. The expertise in molecular biology and cell signaling will be provided for the PIs of the other projects as needed.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
2P01DK050305-11
Application #
6334511
Study Section
Special Emphasis Panel (ZDK1-GRB-C (J3))
Project Start
1989-09-30
Project End
2005-04-30
Budget Start
Budget End
Support Year
11
Fiscal Year
2000
Total Cost
$186,685
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Sokol, Caroline L; Luster, Andrew D (2015) The chemokine system in innate immunity. Cold Spring Harb Perspect Biol 7:
Adair, Brian D; Xiong, Jian-Ping; Alonso, José Luis et al. (2013) EM structure of the ectodomain of integrin CD11b/CD18 and localization of its ligand-binding site relative to the plasma membrane. PLoS One 8:e57951
Gupta, Vineet; Alonso, Jose Luis; Sugimori, Takashi et al. (2008) Role of the beta-subunit arginine/lysine finger in integrin heterodimer formation and function. J Immunol 180:1713-8
Gupta, Vineet; Gylling, Annette; Alonso, Jose Luis et al. (2007) The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18. Blood 109:3513-20
Sackett, Sara D; Fulmer, James T; Friedman, Joshua R et al. (2007) Foxl1-Cre BAC transgenic mice: a new tool for gene ablation in the gastrointestinal mesenchyme. Genesis 45:518-22
Colvin, Richard A; Campanella, Gabriele S V; Manice, Lindsay A et al. (2006) CXCR3 requires tyrosine sulfation for ligand binding and a second extracellular loop arginine residue for ligand-induced chemotaxis. Mol Cell Biol 26:5838-49
Hong, Song; Tjonahen, Eric; Morgan, Elizabeth L et al. (2005) Rainbow trout (Oncorhynchus mykiss) brain cells biosynthesize novel docosahexaenoic acid-derived resolvins and protectins-Mediator lipidomic analysis. Prostaglandins Other Lipid Mediat 78:107-16
Arnaout, M A; Mahalingam, B; Xiong, J-P (2005) Integrin structure, allostery, and bidirectional signaling. Annu Rev Cell Dev Biol 21:381-410
Means, Terry K; Latz, Eicke; Hayashi, Fumitaka et al. (2005) Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J Clin Invest 115:407-17
Devchand, Pallavi R; Schmidt, Birgitta A; Primo, Valeria C et al. (2005) A synthetic eicosanoid LX-mimetic unravels host-donor interactions in allogeneic BMT-induced GvHD to reveal an early protective role for host neutrophils. FASEB J 19:203-10

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