The administrative core, directed by Dr. Susan Taylor, will perform all of the administrative functions required by the program. To achieve this, we have established a Project Manager;Juniper Pennypacker who will work closely with Dr. Taylor, with each project PI, and with each of the core leaders. This will involve accounting, organization of scientific interactions, organization and coordination of monthly meetings, organization and coordination for invited speakers to the UCSD campus, organization and coordination of an workshops in San Diego and preparation of manuscripts. All of the investigators are on the UCSD campus except for John Scott who is at the Vollum Institute in Portland, Oregon. The UCSD investigators are not all, however, in contiguous laboratories, but this is not a barrier to collaborative interactions. This is not typical on other campuses A major asset is the involvement of the San Diego Supercomputer Center which is also housed on the UCSD campus. Its resources will be routinely used by this Program Project. We have a senior bioinformatics specialist who will be financed primarily by matching funds provided by UCSD and supplemented by Core E. This individual interfaces closely with Administrative Core E and will link the structure, genetics, biochemical, and imaging components of the program. In addition, he will interface with other bioinformatics initiatives at UCSD including the Protein Data Bank (PDB), the National Center for Microscopy and Imaging Research (NCMIR) headed by Mark Ellisman who also heads Core C, and a mitochondria data base at SDSC.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK054441-11
Application #
7981358
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
11
Fiscal Year
2009
Total Cost
$66,034
Indirect Cost
Name
University of California San Diego
Department
Type
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Flippo, Kyle H; Gnanasekaran, Aswini; Perkins, Guy A et al. (2018) AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission. J Neurosci 38:8233-8242
Sengupta, Soham; Nechushtai, Rachel; Jennings, Patricia A et al. (2018) Phylogenetic analysis of the CDGSH iron-sulfur binding domain reveals its ancient origin. Sci Rep 8:4840
Haushalter, Kristofer J; Casteel, Darren E; Raffeiner, Andrea et al. (2018) Phosphorylation of protein kinase A (PKA) regulatory subunit RI? by protein kinase G (PKG) primes PKA for catalytic activity in cells. J Biol Chem 293:4411-4421
Smith, F Donelson; Esseltine, Jessica L; Nygren, Patrick J et al. (2017) Local protein kinase A action proceeds through intact holoenzymes. Science 356:1288-1293
Parker, Seth J; Svensson, Robert U; Divakaruni, Ajit S et al. (2017) LKB1 promotes metabolic flexibility in response to energy stress. Metab Eng 43:208-217
Nystoriak, Matthew A; Nieves-CintrĂ³n, Madeline; Patriarchi, Tommaso et al. (2017) Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes. Sci Signal 10:
Ilouz, Ronit; Lev-Ram, Varda; Bushong, Eric A et al. (2017) Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain. Elife 6:
Nygren, Patrick J; Mehta, Sohum; Schweppe, Devin K et al. (2017) Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity. Elife 6:
Aggarwal-Howarth, Stacey; Scott, John D (2017) Pseudoscaffolds and anchoring proteins: the difference is in the details. Biochem Soc Trans 45:371-379
Inupakutika, Madhuri A; Sengupta, Soham; Nechushtai, Rachel et al. (2017) Phylogenetic analysis of eukaryotic NEET proteins uncovers a link between a key gene duplication event and the evolution of vertebrates. Sci Rep 7:42571

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