Abstract

The project focuses on the concept that chronic activation of infiammatory pathways and that the macro- phage/adipocyte nexus provides a l

Public Health Relevance

Insulin resistance is a key feature in Type 2 diabetes mellitus, and macrophage mediated chronic tissue inflammation is an Important etiologic component in this insulin resistant state. This project should elucidate novel actions of anti-inflammatory signaling, and reveal the specific mechanisms underlying the anti-inflam- matory and insulin sensitizing effects of GPR120/omega 3 fatty acids. An improved basic understanding of these cellular events has the potential to lead to new therapeutic opportunities.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK054441-18
Application #
9245677
Study Section
Special Emphasis Panel (ZDK1-GRB-6)
Project Start
Project End
2019-03-31
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
18
Fiscal Year
2017
Total Cost
$313,876
Indirect Cost
$111,375

  Institution

Name
University of California San Diego
Department
Type
Domestic Higher Education
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Flippo, Kyle H; Gnanasekaran, Aswini; Perkins, Guy A et al. (2018) AKAP1 Protects from Cerebral Ischemic Stroke by Inhibiting Drp1-Dependent Mitochondrial Fission. J Neurosci 38:8233-8242
Sengupta, Soham; Nechushtai, Rachel; Jennings, Patricia A et al. (2018) Phylogenetic analysis of the CDGSH iron-sulfur binding domain reveals its ancient origin. Sci Rep 8:4840
Haushalter, Kristofer J; Casteel, Darren E; Raffeiner, Andrea et al. (2018) Phosphorylation of protein kinase A (PKA) regulatory subunit RI? by protein kinase G (PKG) primes PKA for catalytic activity in cells. J Biol Chem 293:4411-4421
Sastri, Mira; Darshi, Manjula; Mackey, Mason et al. (2017) Sub-mitochondrial localization of the genetic-tagged mitochondrial intermembrane space-bridging components Mic19, Mic60 and Sam50. J Cell Sci 130:3248-3260
Smith, F Donelson; Esseltine, Jessica L; Nygren, Patrick J et al. (2017) Local protein kinase A action proceeds through intact holoenzymes. Science 356:1288-1293
Parker, Seth J; Svensson, Robert U; Divakaruni, Ajit S et al. (2017) LKB1 promotes metabolic flexibility in response to energy stress. Metab Eng 43:208-217
Nystoriak, Matthew A; Nieves-Cintrón, Madeline; Patriarchi, Tommaso et al. (2017) Ser1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes. Sci Signal 10:
Ilouz, Ronit; Lev-Ram, Varda; Bushong, Eric A et al. (2017) Isoform-specific subcellular localization and function of protein kinase A identified by mosaic imaging of mouse brain. Elife 6:
Nygren, Patrick J; Mehta, Sohum; Schweppe, Devin K et al. (2017) Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity. Elife 6:
Aggarwal-Howarth, Stacey; Scott, John D (2017) Pseudoscaffolds and anchoring proteins: the difference is in the details. Biochem Soc Trans 45:371-379

Showing the most recent 10 out of 216 publications