Abstract

The Physiology and Assay Core will provide centralized assays of hormones and metabolites, as well as body composition measurements and measurements of O2 consumption to the Projects. Eleven aims in four projects will utilize this facility. The centralization of these services in one laboratory will enhance quality control, and provide economy of scale in ordering and using reagents.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK056116-02
Application #
6349100
Study Section
Project Start
2000-08-01
Project End
2001-07-31
Budget Start
Budget End
Support Year
2
Fiscal Year
2000
Total Cost
$209,314
Indirect Cost

  Institution

Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Sohn, Jong-Woo; Elmquist, Joel K; Williams, Kevin W (2013) Neuronal circuits that regulate feeding behavior and metabolism. Trends Neurosci 36:504-12
Robins, S C; Stewart, I; McNay, D E et al. (2013) ?-Tanycytes of the adult hypothalamic third ventricle include distinct populations of FGF-responsive neural progenitors. Nat Commun 4:2049
Kawashima, Junji; Alquier, Thierry; Tsuji, Youki et al. (2012) Ca2+/calmodulin-dependent protein kinase kinase is not involved in hypothalamic AMP-activated protein kinase activation by neuroglucopenia. PLoS One 7:e36335
Dagon, Yossi; Hur, Elizabeth; Zheng, Bin et al. (2012) p70S6 kinase phosphorylates AMPK on serine 491 to mediate leptin's effect on food intake. Cell Metab 16:104-12
McNay, David E G; Briançon, Nadege; Kokoeva, Maia V et al. (2012) Remodeling of the arcuate nucleus energy-balance circuit is inhibited in obese mice. J Clin Invest 122:142-52
Pulinilkunnil, Thomas; He, Huamei; Kong, Dong et al. (2011) Adrenergic regulation of AMP-activated protein kinase in brown adipose tissue in vivo. J Biol Chem 286:8798-809
Vella, Kristen R; Ramadoss, Preeti; Lam, Francis S et al. (2011) NPY and MC4R signaling regulate thyroid hormone levels during fasting through both central and peripheral pathways. Cell Metab 14:780-90
Loh, Kim; Fukushima, Atsushi; Zhang, Xinmei et al. (2011) Elevated hypothalamic TCPTP in obesity contributes to cellular leptin resistance. Cell Metab 14:684-99
Chiappini, Franck; Cunha, Lucas L; Harris, Jamie C et al. (2011) Lack of cAMP-response element-binding protein 1 in the hypothalamus causes obesity. J Biol Chem 286:8094-105
Briancon, Nadege; McNay, David E; Maratos-Flier, Eleftheria et al. (2010) Combined neural inactivation of suppressor of cytokine signaling-3 and protein-tyrosine phosphatase-1B reveals additive, synergistic, and factor-specific roles in the regulation of body energy balance. Diabetes 59:3074-84

Showing the most recent 10 out of 96 publications