This core measures serum, serum ultrafiltrate, and urine chemistries and calculates urine supersaturations (SS) for human (Projects by Coe and Lingeman) and pig {Project by Evan) protocols, as well as performing assays of serum oxalate (Project core1). The core also performs assays to measure upper limit of metastability with respect to calcium oxalate and calcium phosphate in urine (Projects by Coe and Lingeman). The core measures iothalamate in serum and urine for calculation of iothalamate clearances (Project by Coe). Calculation of euglycemic-hyperinsulinemic glucose clamp induced glucose utilization will be done (Projectby Coe) in collaboration with the Diabetes Research and Training Center. Peripheral blood monocyte vitamin D receptor levels (PBM VDR) will be determined in patients studied in the proposed GCRC protocols (Project by Coe). Assays of protein abundance (by Western blot)will be carried out for VDR, calcium receptor (CaR), calbindin 9 and calbindin 28 in renal cortical biopsy specimens obtained from Project by Lingeman; mRNA expression levels will be measured for VDR and CaR.
| Williams Jr, James C; Borofsky, Michael S; Bledsoe, Sharon B et al. (2018) Papillary Ductal Plugging is a Mechanism for Early Stone Retention in Brushite Stone Disease. J Urol 199:186-192 |
| Worcester, Elaine M; Bergsland, Kristin J; Gillen, Daniel L et al. (2018) Mechanism for higher urine pH in normal women compared with men. Am J Physiol Renal Physiol 314:F623-F629 |
| Bergsland, Kristin J; Coe, Fredric L; Parks, Joan H et al. (2018) Evidence for a role of PDZ domain-containing proteins to mediate hypophosphatemia in calcium stone formers. Nephrol Dial Transplant 33:759-770 |
| Kleinguetl, Colin; Williams Jr, James C; Ibrahim, Samar A et al. (2017) Calcium Tartrate Tetrahydrate, Case Report of a Novel Human Kidney Stone. J Endourol Case Rep 3:192-195 |
| Mulay, Shrikant R; Eberhard, Jonathan N; Desai, Jyaysi et al. (2017) Hyperoxaluria Requires TNF Receptors to Initiate Crystal Adhesion and Kidney Stone Disease. J Am Soc Nephrol 28:761-768 |
| Winfree, Seth; Khan, Shehnaz; Micanovic, Radmila et al. (2017) Quantitative Three-Dimensional Tissue Cytometry to Study Kidney Tissue and Resident Immune Cells. J Am Soc Nephrol 28:2108-2118 |
| Borofsky, Michael S; Dauw, Casey A; York, Nadya et al. (2017) Accuracy of daily fluid intake measurements using a ""smart"" water bottle. Urolithiasis : |
| Winfree, Seth; Ferkowicz, Michael J; Dagher, Pierre C et al. (2017) Large-scale 3-dimensional quantitative imaging of tissues: state-of-the-art and translational implications. Transl Res 189:1-12 |
| Cohen, Andrew J; Borofsky, Michael S; Anderson, Blake B et al. (2017) Endoscopic Evidence That Randall's Plaque is Associated with Surface Erosion of the Renal Papilla. J Endourol 31:85-90 |
| Gilad, Ron; Williams Jr, James C; Usman, Kalba D et al. (2017) Interpreting the results of chemical stone analysis in the era of modern stone analysis techniques. J Nephrol 30:135-140 |
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