The Molecular, Cellular and Animal Model Core (Core B) will provide reagents to assist in the study of calcium, InsP3R, MAP kinases/phosphatases and OGT signaling in the liver. The core will assist in the development and characterization of expression plasmids, siRNA and lentiviral constructs as requested for use in the individual projects. The core will serve as a central repository for all the reagents generated by the four projects and assist in their distribution to other laboratories outside of the institution. The core will include dedicated personnel and will be located within the Director's laboratory.
The goal of Core B will be to serve as a central source for the generation and distribution of key reagents used commonly throughout the Program Project. The core will provide centralized services for genotyping and standardization of implementing animal models for the study of liver injury. The core will be responsible for disseminating reagents to the scientific community.
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| Boeckel, Göran R; Ehrlich, Barbara E (2018) NCS-1 is a regulator of calcium signaling in health and disease. Biochim Biophys Acta Mol Cell Res : |
| Lawan, Ahmed; Min, Kisuk; Zhang, Lei et al. (2018) Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node That Regulates Obesity-Induced Insulin Resistance. Diabetes 67:624-635 |
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| Lemos, Fernanda O; Ehrlich, Barbara E (2018) Polycystin and calcium signaling in cell death and survival. Cell Calcium 69:37-45 |
| Giehl, Esther; Lemos, Fernanda O; Huang, Yan et al. (2017) Polycystin 2-dependent cardio-protective mechanisms revealed by cardiac stress. Pflugers Arch 469:1507-1517 |
| Feriod, Colleen N; Oliveira, Andre Gustavo; Guerra, Mateus T et al. (2017) Hepatic Inositol 1,4,5 Trisphosphate Receptor Type 1 Mediates Fatty Liver. Hepatol Commun 1:23-35 |
| Kruglov, Emma; Ananthanarayanan, Meenakshisundaram; Sousa, Pedro et al. (2017) Type 2 inositol trisphosphate receptor gene expression in hepatocytes is regulated by cyclic AMP. Biochem Biophys Res Commun 486:659-664 |
| Lawan, Ahmed; Bennett, Anton M (2017) Mitogen-Activated Protein Kinase Regulation in Hepatic Metabolism. Trends Endocrinol Metab 28:868-878 |
| Ruan, Hai-Bin; Ma, Yina; Torres, Sara et al. (2017) Calcium-dependent O-GlcNAc signaling drives liver autophagy in adaptation to starvation. Genes Dev 31:1655-1665 |
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