The primary purpose of Clinical Core A is to provide access to patients with ANCA-associated small vessel vasculitis (SW) in order to obtain biological samples in conjunction with clinical information for the use in three of the proposed projects of this program project. Access to this patient population and to patients at different disease stages is critical for the successful completion of these projects. Clinical stages of particular interest in this patient population include: remission, remission on therapy, treatment resistance, relapse and end stage renal disease. The Core will also be responsible for processing and storing biologic samples, as well as managing the database with respect to consent forms, labeling and storage locations of specimens, and clinical assessment of disease stages and outcomes. The Core will also provide the study design and statistical expertise needed to publish and present abstracts andmanuscripts. The faculty and staff who comprise the Core have a long term commitment to research in this arena and have well documented track record of publishing abstracts and manuscripts with the principal and co-investigators, with a particular focus in the area of vasculitis.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK058335-07
Application #
7311636
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
7
Fiscal Year
2006
Total Cost
$88,131
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
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Weiner, Maria; Bjørneklett, Rune; Hrušková, Zdenka et al. (2018) Proteinase-3 and myeloperoxidase serotype in relation to demographic factors and geographic distribution in anti-neutrophil cytoplasmic antibody-associated glomerulonephritis. Nephrol Dial Transplant :
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Jones, Britta E; Yang, Jiajin; Muthigi, Akhil et al. (2017) Gene-Specific DNA Methylation Changes Predict Remission in Patients with ANCA-Associated Vasculitis. J Am Soc Nephrol 28:1175-1187
Merkel, Peter A; Xie, Gang; Monach, Paul A et al. (2017) Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis. Arthritis Rheumatol 69:1054-1066

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