Abstract

The Matrix Biology Core will have three major components that are required for the success of all 4 projectsproposed in this program project grant. These include: a) Production of proteins for biological assays fordetermination of their structures and interactions with other proteins (Projects 1-4); b) Mass spectrometry (MS)(Projects 1-4) and c) Biochemical determination of the composition of glomerular basement membranes(Project 4).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
2P01DK065123-07
Application #
7568459
Study Section
Special Emphasis Panel (ZDK1-GRB-W (M1))
Project Start
2008-08-01
Project End
2013-07-31
Budget Start
2008-08-01
Budget End
2009-07-31
Support Year
7
Fiscal Year
2008
Total Cost
$170,463
Indirect Cost

  Institution

Name
Vanderbilt University Medical Center
Department
Type
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212

  Publications

McCarson, Kenneth E; Winter, Michelle K; Abrahamson, Dale R et al. (2018) Assessing complex movement behaviors in rodent models of neurological disorders. Neurobiol Learn Mem :
Grove, Kerri J; Lareau, Nichole M; Voziyan, Paul A et al. (2018) Imaging mass spectrometry reveals direct albumin fragmentation within the diabetic kidney. Kidney Int 94:292-302
Cummings, Christopher F; Pedchenko, Vadim; Brown, Kyle L et al. (2016) Extracellular chloride signals collagen IV network assembly during basement membrane formation. J Cell Biol 213:479-94
Madu, Hartman; Avance, Josh; Chetyrkin, Sergei et al. (2015) Pyridoxamine protects proteins from damage by hypohalous acids in vitro and in vivo. Free Radic Biol Med 89:83-90
Brown, Kyle L; Darris, Carl; Rose, Kristie Lindsey et al. (2015) Hypohalous acids contribute to renal extracellular matrix damage in experimental diabetes. Diabetes 64:2242-53
Fidler, Aaron L; Vanacore, Roberto M; Chetyrkin, Sergei V et al. (2014) A unique covalent bond in basement membrane is a primordial innovation for tissue evolution. Proc Natl Acad Sci U S A 111:331-6
Chen, Xiwu; Wang, Hongtao; Liao, Hong-Jun et al. (2014) Integrin-mediated type II TGF-? receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling. J Clin Invest 124:3295-310
Pozzi, Ambra; Zent, Roy (2013) Integrins in kidney disease. J Am Soc Nephrol 24:1034-9
Natarajan, Chandramohan; Hata, Aaron N; Hamm, Heidi E et al. (2013) Extracellular loop II modulates GTP sensitivity of the prostaglandin EP3 receptor. Mol Pharmacol 83:206-16
Abrahamson, Dale R; St John, Patricia L; Stroganova, Larysa et al. (2013) Laminin and type IV collagen isoform substitutions occur in temporally and spatially distinct patterns in developing kidney glomerular basement membranes. J Histochem Cytochem 61:706-18

Showing the most recent 10 out of 91 publications