Abstract

Since its establishment in 1985 the Yale Magnetic Resonance Research Center (MRRC) has been a leader in the development and application of MRS technology and 13C isotopic labeling strategies for studying carbohydrate and lipid metabolism in insulin resistance. Much of the initial support for the development of the MRRC core research program came from NIDDK. Recently the MRRC has moved to a new 30,000 square foot building and has added a new 4.0T human MRS/MRI system dedicated to studying metabolism. The primary aim of the MRS/MRI Core will be to provide comprehensive MRS and MRI support on this system for the projects clinical core. Core services provided are i) MRS and MRI methodology at 4.0T for studying brain liver and muscle mitochondrial function ii) metabolic modeling to obtain metabolic fluxes from MRS measurements, iii) MRS/MR system operation and data analysis, and iv) regular quality control measures to ensure the reliability of the MRS and MRI. In addition to being critical for the success of the program project, the MRS and MRI methodology and quality control procedures implemented by the core will benefit all NIDDK investigators (both within and outside Yale) using the facility.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
1P01DK068229-01
Application #
6844970
Study Section
Special Emphasis Panel (ZDK1-GRB-4 (M4))
Project Start
2004-07-01
Project End
2009-06-30
Budget Start
2004-07-01
Budget End
2005-08-31
Support Year
1
Fiscal Year
2004
Total Cost
$208,141
Indirect Cost

  Institution

Name
Yale University
Department
Type
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520

  Publications

Madiraju, Anila K; Qiu, Yang; Perry, Rachel J et al. (2018) Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo. Nat Med 24:1384-1394
Lee, Hui-Young; Gattu, Arijeet K; Camporez, João-Paulo G et al. (2014) Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice. Diabetologia 57:1232-41
Jornayvaz, François R; Shulman, Gerald I (2012) Diacylglycerol activation of protein kinase C? and hepatic insulin resistance. Cell Metab 15:574-84
Samuel, Varman T; Shulman, Gerald I (2012) Mechanisms for insulin resistance: common threads and missing links. Cell 148:852-71
Samuel, Varman T; Petersen, Kitt Falk; Shulman, Gerald I (2010) Lipid-induced insulin resistance: unravelling the mechanism. Lancet 375:2267-77
Petersen, Kitt Falk; Dufour, Sylvie; Hariri, Ali et al. (2010) Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease. N Engl J Med 362:1082-9
Boumezbeur, Fawzi; Mason, Graeme F; de Graaf, Robin A et al. (2010) Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy. J Cereb Blood Flow Metab 30:211-21
Boumezbeur, Fawzi; Petersen, Kitt F; Cline, Gary W et al. (2010) The contribution of blood lactate to brain energy metabolism in humans measured by dynamic 13C nuclear magnetic resonance spectroscopy. J Neurosci 30:13983-91
Mitchell, Catherine S; Savage, David B; Dufour, Sylvie et al. (2010) Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia. J Clin Invest 120:1345-54
Befroy, Douglas E; Falk Petersen, Kitt; Rothman, Douglas L et al. (2009) Assessment of in vivo mitochondrial metabolism by magnetic resonance spectroscopy. Methods Enzymol 457:373-93

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