Abstract

The goal of the Path Core is to accession and prepare well characterized tissue for analysis. This effort will be led by Dr. Noam Harpaz Chief of GI Pathology at the Mount Sinai Medical Center, and two GI pathologists. Both human and mouse components are served by the core. This core will be heavily used by all projects with the following aims:
Specific Aim 1 : To retrieve, process, and distribute suitable specimens for the four Projects as needed (human - projects 1 and 3;murine - projects 2, 3 and 4).
Specific Aim 2 : To stabilize and preserve undistributed tissues for long-term storage and make them available to other Projects or investigators as needed.
Specific Aim 3 : To maintain a detailed tissue database (mouse and human) documenting the anatomic sources, the gross and microscopic pathological characteristics of the individual tissue specimens, and the clinical and pathological data pertaining to the patients (or mice) from whom specimens were derived. .
Specific Aim 4 : To perform blinded histologic evaluation and scoring of inflammation in the different murine models of IBD used in projects 2, 3 and 4. (Dr. Xu).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Research Program Projects (P01)
Project #
5P01DK072201-05
Application #
8136667
Study Section
Special Emphasis Panel (ZDK1)
Project Start
Project End
Budget Start
2010-09-01
Budget End
2011-08-31
Support Year
5
Fiscal Year
2010
Total Cost
$191,397
Indirect Cost

  Institution

Name
Icahn School of Medicine at Mount Sinai
Department
Type
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Barbet, Gaetan; Sander, Leif E; Geswell, Matthew et al. (2018) Sensing Microbial Viability through Bacterial RNA Augments T Follicular Helper Cell and Antibody Responses. Immunity 48:584-598.e5
Meisel, Marlies; Hinterleitner, Reinhard; Pacis, Alain et al. (2018) Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host. Nature 557:580-584
Blander, J Magarian (2018) Regulation of the Cell Biology of Antigen Cross-Presentation. Annu Rev Immunol 36:717-753
Blander, J Magarian; Barbet, Gaetan (2018) Exploiting vita-PAMPs in vaccines. Curr Opin Pharmacol 41:128-136
Moretti, Julien; Roy, Soumit; Bozec, Dominique et al. (2017) STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum. Cell 171:809-823.e13
Moretti, Julien; Blander, J Magarian (2017) Cell-autonomous stress responses in innate immunity. J Leukoc Biol 101:77-86
Blander, J Magarian; Longman, Randy S; Iliev, Iliyan D et al. (2017) Regulation of inflammation by microbiota interactions with the host. Nat Immunol 18:851-860
Blander, J Magarian (2017) The many ways tissue phagocytes respond to dying cells. Immunol Rev 277:158-173
Tang, Mei San; Bowcutt, Rowann; Leung, Jacqueline M et al. (2017) Integrated Analysis of Biopsies from Inflammatory Bowel Disease Patients Identifies SAA1 as a Link Between Mucosal Microbes with TH17 and TH22 Cells. Inflamm Bowel Dis 23:1544-1554
Campisi, Laura; Barbet, Gaetan; Ding, Yi et al. (2016) Apoptosis in response to microbial infection induces autoreactive TH17 cells. Nat Immunol 17:1084-92

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