Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
2P01ES000597-16
Application #
3964928
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
16
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Type
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Soman, N R; Wogan, G N (1993) Activation of the c-Ki-ras oncogene in aflatoxin B1-induced hepatocellular carcinoma and adenoma in the rat: detection by denaturing gradient gel electrophoresis. Proc Natl Acad Sci U S A 90:2045-9
Keohavong, P; Ling, L; Dias, C et al. (1993) Predominant mutations induced by the Thermococcus litoralis, vent DNA polymerase during DNA amplification in vitro. PCR Methods Appl 2:288-92
Oleykowski, C A; Mayernik, J A; Lim, S E et al. (1993) Repair of aflatoxin B1 DNA adducts by the UvrABC endonuclease of Escherichia coli. J Biol Chem 268:7990-8002
Sheabar, F Z; Groopman, J D; Qian, G S et al. (1993) Quantitative analysis of aflatoxin-albumin adducts. Carcinogenesis 14:1203-8
Larson, P S; McMahon, G; Wogan, G N (1993) Modulation of c-myc gene expression in rat livers by aflatoxin B1 exposure and age. Fundam Appl Toxicol 20:316-24
Tannenbaum, S R; Skipper, P L; Wishnok, J S et al. (1993) Characterization of various classes of protein adducts. Environ Health Perspect 99:51-5
Keohavong, P; Thilly, W G (1992) Determination of point mutational spectra of benzo[a]pyrene-diol epoxide in human cells. Environ Health Perspect 98:215-9
Keohavong, P; Thilly, W G (1992) Mutational spectrometry: a general approach for hot-spot point mutations in selectable genes. Proc Natl Acad Sci U S A 89:4623-7
Groopman, J D; Hasler, J A; Trudel, L J et al. (1992) Molecular dosimetry in rat urine of aflatoxin-N7-guanine and other aflatoxin metabolites by multiple monoclonal antibody affinity chromatography and immunoaffinity/high performance liquid chromatography. Cancer Res 52:267-74
Wogan, G N (1992) Aflatoxins as risk factors for hepatocellular carcinoma in humans. Cancer Res 52:2114s-2118s

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