Abstract

The critical procedures in this unit are measurements of airway resistance, breathing frequency, and tidal volume, and administering the test for airway hyperresponsiveness for specific allergen, HDMA and nonspecific (methacholine, phenyl biquanine) challenges. These data will be expressed as CDA 200 or EC 200 Raw, the concentration or dose of challenge needed to double airway resistance. Raw will be measured using Transfer Impedance which involves an established model of airway mechanics to predict airway resistance from wave forms generated by acoustical speakers. The wave forms are sensitive to changes in airway caliber and are determined from the pressure recordings in the pleythsmograph box and the airway flow recorded in pneumotchograph connected to the monkey by a face mask or endotracheal tube.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES000628-29
Application #
6656492
Study Section
Special Emphasis Panel (ZES1)
Project Start
2002-09-04
Project End
2003-06-30
Budget Start
Budget End
Support Year
29
Fiscal Year
2002
Total Cost
$157,210
Indirect Cost

  Institution

Name
University of California Davis
Department
Type
DUNS #
094878337
City
Davis
State
CA
Country
United States
Zip Code
95618

  Publications

Crowley, Candace M; Fontaine, Justin H; Gerriets, Joan E et al. (2017) Early life allergen and air pollutant exposures alter longitudinal blood immune profiles in infant rhesus monkeys. Toxicol Appl Pharmacol 328:60-69
Hsia, Connie C W; Hyde, Dallas M; Weibel, Ewald R (2016) Lung Structure and the Intrinsic Challenges of Gas Exchange. Compr Physiol 6:827-95
Herring, Matt J; Avdalovic, Mark V; Lasley, Bill et al. (2016) Elderly Female Rhesus Macaques Preserve Lung Alveoli With Estrogen/Progesterone Therapy. Anat Rec (Hoboken) 299:973-8
Lynn, Therese M; Molloy, Emer L; Masterson, Joanne C et al. (2016) SMAD Signaling in the Airways of Healthy Rhesus Macaques versus Rhesus Macaques with Asthma Highlights a Relationship Between Inflammation and Bone Morphogenetic Proteins. Am J Respir Cell Mol Biol 54:562-73
Van Winkle, Laura S; Bein, Keith; Anderson, Donald et al. (2015) Biological dose response to PM2.5: effect of particle extraction method on platelet and lung responses. Toxicol Sci 143:349-59
Herring, M J; Putney, L F; St George, J A et al. (2015) Early life exposure to allergen and ozone results in altered development in adolescent rhesus macaque lungs. Toxicol Appl Pharmacol 283:35-41
Madl, Amy K; Plummer, Laurel E; Carosino, Christopher et al. (2014) Nanoparticles, lung injury, and the role of oxidant stress. Annu Rev Physiol 76:447-65
Herring, Matt J; Putney, Lei F; Wyatt, Gregory et al. (2014) Growth of alveoli during postnatal development in humans based on stereological estimation. Am J Physiol Lung Cell Mol Physiol 307:L338-44
Moore, Brian D; Hyde, Dallas M; Miller, Lisa A et al. (2014) Persistence of serotonergic enhancement of airway response in a model of childhood asthma. Am J Respir Cell Mol Biol 51:77-85
Murphy, Shannon R; Oslund, Karen L; Hyde, Dallas M et al. (2014) Ozone-induced airway epithelial cell death, the neurokinin-1 receptor pathway, and the postnatal developing lung. Am J Physiol Lung Cell Mol Physiol 307:L471-81

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