The general objective of this program project continues to be to gain a better understanding of the long-range health effect of lead (Pb) exposure, beginning at birth and continuing on into the early school years. The main emphasis of the study continues to be on the adverse neurological effects, including cognition, psychomotor performance postural balance and physical development. The implications of moderate Pb-related deficit in I.Q. seen by us and others in the preschool years for later competence need to be determined. These moderate deficits may indeed become more severe as the child faces progressively increasing challenges to his cognitive abilities, and social adjustments. Toward that end we propose to assess the intellectual attainment, academic achievement, verbal-language abilities, social adjustment and discrete aspects of neuromotor performance. As the subjects enter into school during the renewal period, it will now be possible to better assess the full impact of earlier developmental effects on social and academic performance. Toward that end neurobehavioral testing and blood lead (PbB) determinants will continue at 72 and 78 months.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES001566-16
Application #
2153054
Study Section
Environmental Health Sciences Review Committee (EHS)
Project Start
1979-07-01
Project End
1996-08-31
Budget Start
1994-09-01
Budget End
1995-08-31
Support Year
16
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Cincinnati
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Bhattacharya, Amit; Shukla, Rakesh; Dietrich, Kim N et al. (2006) Effect of early lead exposure on the maturation of children's postural balance: a longitudinal study. Neurotoxicol Teratol 28:376-85
Spitz, H; Jenkins, M; Lodwick, J et al. (2000) A new anthropometric phantom for calibrating in vivo measurements of stable lead in the human leg using x-ray fluorescence. Health Phys 78:159-69
Bhattacharya, A; Smelser, D T; Berger, O et al. (1998) The effect of succimer therapy in lead intoxication using postural balance as a measure: a case study in a nine year old child. Neurotoxicology 19:57-64
Bhattacharya, A; Shukla, R; Dietrich, K et al. (1995) Effect of early lead exposure on children's postural balance. Dev Med Child Neurol 37:861-78
Dietrich, K N; Berger, O G; Succop, P A et al. (1993) The developmental consequences of low to moderate prenatal and postnatal lead exposure: intellectual attainment in the Cincinnati Lead Study Cohort following school entry. Neurotoxicol Teratol 15:37-44
Dietrich, K N; Berger, O G; Succop, P A (1993) Lead exposure and the motor developmental status of urban six-year-old children in the Cincinnati Prospective Study. Pediatrics 91:301-7
Bhattacharya, A; Shukla, R; Dietrich, K N et al. (1993) Functional implications of postural disequilibrium due to lead exposure. Neurotoxicology 14:179-89
Dietrich, K N; Succop, P A; Berger, O G et al. (1992) Lead exposure and the central auditory processing abilities and cognitive development of urban children: the Cincinnati Lead Study cohort at age 5 years. Neurotoxicol Teratol 14:51-6
Buncher, C R; Succop, P A; Dietrich, K N (1991) Structural equation modeling in environmental risk assessment. Environ Health Perspect 90:209-13
Koo, W W; Succop, P A; Bornschein, R L et al. (1991) Serum vitamin D metabolites and bone mineralization in young children with chronic low to moderate lead exposure. Pediatrics 87:680-7

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