Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES003347-02
Application #
4693073
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Louisiana State University A&M Col Baton Rouge
Department
Type
DUNS #
075050765
City
Baton Rouge
State
LA
Country
United States
Zip Code
70803
Drost, J B; Lee, W R (1995) Biological basis of germline mutation: comparisons of spontaneous germline mutation rates among drosophila, mouse, and human. Environ Mol Mutagen 25 Suppl 26:48-64
Henehan, G T; Chang, S H; Oppenheimer, N J (1995) Aldehyde dehydrogenase activity of Drosophila melanogaster alcohol dehydrogenase: burst kinetics at high pH and aldehyde dismutase activity at physiological pH. Biochemistry 34:12294-301
Chenevert, S W; Fossett, N G; Chang, S H et al. (1995) Amino acids important in enzyme activity and dimer stability for Drosophila alcohol dehydrogenase. Biochem J 308 ( Pt 2):419-23
Fossett, N G; Byrne, B J; Kelley, S J et al. (1994) The influence of large deletions on the mutation frequency induced by tritiated water and X-radiation in male Drosophila melanogaster post-meiotic germ cells. Mutat Res 307:213-22
Chen, Z; Tsigelny, I; Lee, W R et al. (1994) Adding a positive charge at residue 46 of Drosophila alcohol dehydrogenase increases cofactor specificity for NADP+. FEBS Lett 356:81-5
Chen, Z; Jiang, J C; Lin, Z G et al. (1993) Site-specific mutagenesis of Drosophila alcohol dehydrogenase: evidence for involvement of tyrosine-152 and lysine-156 in catalysis. Biochemistry 32:3342-6
Jiang, J C; Lee, W R; Chang, S H et al. (1992) Mechanisms for dominance: Adh heterodimer formation in heterozygotes between ENU or X-ray induced null alleles and normal alleles in Drosophila melanogaster. Environ Mol Mutagen 20:260-70
Chen, Z; Lee, W R; Chang, S H (1991) Role of aspartic acid 38 in the cofactor specificity of Drosophila alcohol dehydrogenase. Eur J Biochem 202:263-7
Mahmoud, J; Fossett, N G; Arbour-Reily, P et al. (1991) DNA sequence analysis of X-ray induced Adh null mutations in Drosophila melanogaster. Environ Mol Mutagen 18:157-60
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