Abstract

in the Progress Report. Importantly, the synthetic route employed is generally applicable to the incorporation into DNA of adducts derived from aristolochic acid-l (AA-1) and other AA analogs. The Panel also commented that the progress report does not address previous aims ... there is concern about the ability to mount a successful concerted approach.
Aims 2 and 3 of the orginal proposal were pursued actively, as described in the Progress Report, but did not result in publications. In the case of Aim 2, the selectivity of the lexitropsins could not be reproduced at the level of oligomeric DNA. The premise of Aim 3; that oxidation products of bisphenol A are responsible for their mutagenic behaviour, could not be confirmed. We therefore turned to an project directly related to the long-term goals of this PPG research and, in developing a novel method for introducing benzpyrenediolepoxide adducts

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES004068-23
Application #
8274431
Study Section
Special Emphasis Panel (ZES1)
Project Start
Project End
2014-04-30
Budget Start
2011-07-01
Budget End
2013-04-30
Support Year
23
Fiscal Year
2011
Total Cost
$390,727
Indirect Cost

  Institution

Name
State University New York Stony Brook
Department
Type
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794

  Publications

Yun, Byeong Hwa; Guo, Jingshu; Turesky, Robert J (2018) Formalin-Fixed Paraffin-Embedded Tissues-An Untapped Biospecimen for Biomonitoring DNA Adducts by Mass Spectrometry. Toxics 6:
Jelakovi?, Bojan; Vukovi? Lela, Ivana; Karanovi?, Sandra et al. (2015) Chronic dietary exposure to aristolochic acid and kidney function in native farmers from a Croatian endemic area and Bosnian immigrants. Clin J Am Soc Nephrol 10:215-23
Romanov, Victor; Whyard, Terry C; Waltzer, Wayne C et al. (2015) Aristolochic acid-induced apoptosis and G2 cell cycle arrest depends on ROS generation and MAP kinases activation. Arch Toxicol 89:47-56
Yun, Byeong Hwa; Sidorenko, Viktoriya S; Rosenquist, Thomas A et al. (2015) New Approaches for Biomonitoring Exposure to the Human Carcinogen Aristolochic Acid. Toxicol Res (Camb) 4:763-776
Castells, Xavier; Karanovi?, Sandra; Ardin, Maude et al. (2015) Low-Coverage Exome Sequencing Screen in Formalin-Fixed Paraffin-Embedded Tumors Reveals Evidence of Exposure to Carcinogenic Aristolochic Acid. Cancer Epidemiol Biomarkers Prev 24:1873-81
Jelakovi?, Bojan; Nikoli?, Jovan; Radovanovi?, Zoran et al. (2014) Consensus statement on screening, diagnosis, classification and treatment of endemic (Balkan) nephropathy. Nephrol Dial Transplant 29:2020-7
Ivkovi?, Vanja; Karanovi?, Sandra; Fištrek Prli?, Margareta et al. (2014) Is herbal tea consumption a factor in endemic nephropathy? Eur J Epidemiol 29:221-4
Yun, Byeong Hwa; Yao, Lihua; Jelakovi?, Bojan et al. (2014) Formalin-fixed paraffin-embedded tissue as a source for quantitation of carcinogen DNA adducts: aristolochic acid as a prototype carcinogen. Carcinogenesis 35:2055-61
Attaluri, Sivaprasad; Iden, Charles R; Bonala, Radha R et al. (2014) Total synthesis of the aristolochic acids, their major metabolites, and related compounds. Chem Res Toxicol 27:1236-42
Sidorenko, Viktoriya S; Attaluri, Sivaprasad; Zaitseva, Irina et al. (2014) Bioactivation of the human carcinogen aristolochic acid. Carcinogenesis 35:1814-22

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