Abstract

The role of the Synthetic Organic Chemistry Core is to provide candidate pharmaceuticals both as probes of N0S and as potential therapeutic agents. This core facility will support the individual projects by synthesizing three classes of agents: 1) novel, rationally- designed guanidine mimics as candidate N0S inhibitors; 2) new aza- heterocyclic probes of the N0S heme site and computational support to understand their modes of action; and, 3) N0-releasing candidate depot polymers based on bio-compatible macromolecular carriers.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES006897-03
Application #
6203500
Study Section
Project Start
1999-09-01
Project End
2000-08-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Medicine & Dentistry of NJ
Department
Type
DUNS #
622146454
City
Piscataway
State
NJ
Country
United States
Zip Code
08854

  Publications

Jan, Yi-Hua; Richardson, Jason R; Baker, Angela A et al. (2016) Novel approaches to mitigating parathion toxicity: targeting cytochrome P450-mediated metabolism with menadione. Ann N Y Acad Sci 1378:80-86
Kazanecki, Christian C; Kowalski, Aaron J; Ding, Tony et al. (2007) Characterization of anti-osteopontin monoclonal antibodies: Binding sensitivity to post-translational modifications. J Cell Biochem 102:925-35
Kazanecki, Christian C; Uzwiak, Dana J; Denhardt, David T (2007) Control of osteopontin signaling and function by post-translational phosphorylation and protein folding. J Cell Biochem 102:912-24
Gray, Joshua P; Heck, Diane E; Mishin, Vladimir et al. (2007) Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD(P)H:paraquat oxidoreductase: identification of the enzyme as thioredoxin reductase. J Biol Chem 282:7939-49
Ishijima, Muneaki; Ezura, Yoichi; Tsuji, Kunikazu et al. (2006) Osteopontin is associated with nuclear factor kappaB gene expression during tail-suspension-induced bone loss. Exp Cell Res 312:3075-83
Heck, Diane E; Kagan, Valerian E; Shvedova, Anna A et al. (2005) An epigrammatic (abridged) recounting of the myriad tales of astonishing deeds and dire consequences pertaining to nitric oxide and reactive oxygen species in mitochondria with an ancillary missive concerning the origins of apoptosis. Toxicology 208:259-71
Vetrano, Anna M; Heck, Diane E; Mariano, Thomas M et al. (2005) Characterization of the oxidase activity in mammalian catalase. J Biol Chem 280:35372-81
Martey, Christine A; Vetrano, Anna M; Whittemore, Marilyn S et al. (2005) Inhibition of interferon-gamma signaling by a mercurio-substituted dihydropsoralen in murine keratinocytes. Biochem Pharmacol 70:1726-34
Fakhrzadeh, Ladan; Laskin, Jeffrey D; Gardner, Carol R et al. (2004) Superoxide dismutase-overexpressing mice are resistant to ozone-induced tissue injury and increases in nitric oxide and tumor necrosis factor-alpha. Am J Respir Cell Mol Biol 30:280-7
Heck, Diane E; Gerecke, Donald R; Vetrano, Anna M et al. (2004) Solar ultraviolet radiation as a trigger of cell signal transduction. Toxicol Appl Pharmacol 195:288-97

Showing the most recent 10 out of 77 publications