Abstract

The overall goal of this research proposal is to examine the mechanisms by which environmental toxicants adverse;y affect reproductive neuroendocrine development, using the rat as a model. There are four specific aims: The goal of specific aim I is to establish am experimental model for evaluating development.
Specific aim II will test the hypothesis that the GnRH neurosecretory system plays a critical role in environmental toxicant induced stimulation or delay of reproductive development; characterize the mechanisms and compare the effects of the different toxicants.
Specific aim III will test the hypothesis that exposure to environmental toxicants affects the development of neurotransmitter/growth factor system inputs to GnRH neurons, hypothalamine GT1-7 neuronal cell line, which synthesizes and secretes GnRH, methoxychlor, Aroclor 1221, Aroclor 1254, lead and chlorpyrifos affect the GnRH neurosecretory system.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES009584-02
Application #
6203512
Study Section
Project Start
1999-11-01
Project End
2000-10-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
2
Fiscal Year
2000
Total Cost
$103,079
Indirect Cost

  Institution

Name
Mount Sinai School of Medicine
Department
Type
DUNS #
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Dobraca, Dina; Lum, Raymond; Sjödin, Andreas et al. (2018) Urinary biomarkers of polycyclic aromatic hydrocarbons in pre- and peri-pubertal girls in Northern California: Predictors of exposure and temporal variability. Environ Res 165:46-54
Buckley, Jessie P; Quirós-Alcalá, Lesliam; Teitelbaum, Susan L et al. (2018) Associations of prenatal environmental phenol and phthalate biomarkers with respiratory and allergic diseases among children aged 6 and 7?years. Environ Int 115:79-88
Furlong, Melissa; Herring, Amy H; Goldman, Barbara D et al. (2018) Early Life Characteristics and Neurodevelopmental Phenotypes in the Mount Sinai Children's Environmental Health Center. Child Psychiatry Hum Dev 49:534-550
Keil, Alexander P; Daza, Eric J; Engel, Stephanie M et al. (2018) A Bayesian approach to the g-formula. Stat Methods Med Res 27:3183-3204
Windham, Gayle C; Lum, Raymond; Voss, Robert et al. (2017) Age at Pubertal Onset in Girls and Tobacco Smoke Exposure During Pre- and Postnatal Susceptibility Windows. Epidemiology 28:719-727
Buckley, Jessie P; Doherty, Brett T; Keil, Alexander P et al. (2017) Statistical Approaches for Estimating Sex-Specific Effects in Endocrine Disruptors Research. Environ Health Perspect 125:067013
Sheffield, Perry E; Uijttewaal, Simone A M; Stewart, James et al. (2017) Climate Change and Schools: Environmental Hazards and Resiliency. Int J Environ Res Public Health 14:
Furlong, Melissa A; Herring, Amy; Buckley, Jessie P et al. (2017) Prenatal exposure to organophosphorus pesticides and childhood neurodevelopmental phenotypes. Environ Res 158:737-747
Mervish, Nancy A; Teitelbaum, Susan L; Pajak, Ashley et al. (2017) Peripubertal dietary flavonol and lignan intake and age at menarche in a longitudinal cohort of girls. Pediatr Res 82:201-208
Doherty, Brett T; Engel, Stephanie M; Buckley, Jessie P et al. (2017) Prenatal phthalate biomarker concentrations and performance on the Bayley Scales of Infant Development-II in a population of young urban children. Environ Res 152:51-58

Showing the most recent 10 out of 84 publications