The overall goal of this research proposal is to examine the mechanisms by which environmental toxicants adverse;y affect reproductive neuroendocrine development, using the rat as a model. There are four specific aims: The goal of specific aim I is to establish am experimental model for evaluating development.
Specific aim II will test the hypothesis that the GnRH neurosecretory system plays a critical role in environmental toxicant induced stimulation or delay of reproductive development; characterize the mechanisms and compare the effects of the different toxicants.
Specific aim III will test the hypothesis that exposure to environmental toxicants affects the development of neurotransmitter/growth factor system inputs to GnRH neurons, hypothalamine GT1-7 neuronal cell line, which synthesizes and secretes GnRH, methoxychlor, Aroclor 1221, Aroclor 1254, lead and chlorpyrifos affect the GnRH neurosecretory system.

National Institute of Health (NIH)
National Institute of Environmental Health Sciences (NIEHS)
Research Program Projects (P01)
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Mount Sinai School of Medicine
New York
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Dobraca, Dina; Lum, Raymond; Sjödin, Andreas et al. (2018) Urinary biomarkers of polycyclic aromatic hydrocarbons in pre- and peri-pubertal girls in Northern California: Predictors of exposure and temporal variability. Environ Res 165:46-54
Buckley, Jessie P; Quirós-Alcalá, Lesliam; Teitelbaum, Susan L et al. (2018) Associations of prenatal environmental phenol and phthalate biomarkers with respiratory and allergic diseases among children aged 6 and 7?years. Environ Int 115:79-88
Furlong, Melissa; Herring, Amy H; Goldman, Barbara D et al. (2018) Early Life Characteristics and Neurodevelopmental Phenotypes in the Mount Sinai Children's Environmental Health Center. Child Psychiatry Hum Dev 49:534-550
Keil, Alexander P; Daza, Eric J; Engel, Stephanie M et al. (2018) A Bayesian approach to the g-formula. Stat Methods Med Res 27:3183-3204
Furlong, Melissa A; Barr, Dana Boyd; Wolff, Mary S et al. (2017) Prenatal exposure to pyrethroid pesticides and childhood behavior and executive functioning. Neurotoxicology 62:231-238
Singer, Alison B; Wolff, Mary S; Silva, Manori J et al. (2017) Prenatal phthalate exposures and child temperament at 12 and 24 months. Neurotoxicology 62:248-257
Wolff, Mary S; Pajak, Ashley; Pinney, Susan M et al. (2017) Associations of urinary phthalate and phenol biomarkers with menarche in a multiethnic cohort of young girls. Reprod Toxicol 67:56-64
Hiatt, Robert A; Stewart, Susan L; Hoeft, Kristin S et al. (2017) Childhood Socioeconomic Position and Pubertal Onset in a Cohort of Multiethnic Girls: Implications for Breast Cancer. Cancer Epidemiol Biomarkers Prev 26:1714-1721
Windham, Gayle C; Lum, Raymond; Voss, Robert et al. (2017) Age at Pubertal Onset in Girls and Tobacco Smoke Exposure During Pre- and Postnatal Susceptibility Windows. Epidemiology 28:719-727
Buckley, Jessie P; Doherty, Brett T; Keil, Alexander P et al. (2017) Statistical Approaches for Estimating Sex-Specific Effects in Endocrine Disruptors Research. Environ Health Perspect 125:067013

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