Abstract

The overall focus of the Center for Child Environmental Health Risk Research is on mechanisms that define children's susceptibility to pesticides. The Genetic Susceptibility Core will examine differences in genetics (PON1) which affect metabolism and define susceptibility. The functional consequences of these will be assessed in the Neurobehavioral Assessment Facility Core. These studies will be performed in close collaboration with the Molecular Mechanisms Study, which will specifically evaluate the molecular and cellular mechanisms through which pesticides can exert their neurodevelopmental toxicity. In total, these 3 laboratory based studies provide an optimal mix of in vivo and in vitro assessments and molecular, cellular, and genetic evaluations. The Genetic Susceptibility Project will provide information on inter and intraindividual variability for risk characterization modeling by the Risk Characterization Core. Information from the Exposure Assessment Facility Core will ensure that these quantitative assessments are realistic.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES009601-08
Application #
7173280
Study Section
Special Emphasis Panel (ZES1)
Project Start
Project End
Budget Start
2005-11-01
Budget End
2006-10-31
Support Year
8
Fiscal Year
2006
Total Cost
$87,538
Indirect Cost

  Institution

Name
University of Washington
Department
Type
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Ulrich, Angie; Molina, Yamile; Briant, Katherine J et al. (2018) Stress Among Latinos: Does it Vary by Occupation and Agricultural Season? J Occup Environ Med 60:810-814
Griffith, William C; Vigoren, Eric M; Smith, Marissa N et al. (2018) Application of improved approach to evaluate a community intervention to reduce exposure of young children living in farmworker households to organophosphate pesticides. J Expo Sci Environ Epidemiol :
Plascak, Jesse J; Griffith, William C; Workman, Tomomi et al. (2018) Evaluation of the relationship between residential orchard density and dimethyl organophosphate pesticide residues in house dust. J Expo Sci Environ Epidemiol :
Tamaro, Catherine M; Smith, Marissa N; Workman, Tomomi et al. (2018) Characterization of organophosphate pesticides in urine and home environment dust in an agricultural community. Biomarkers 23:174-187
Gibbs, Jenna L; Yost, Michael G; Negrete, Maria et al. (2017) Passive Sampling for Indoor and Outdoor Exposures to Chlorpyrifos, Azinphos-Methyl, and Oxygen Analogs in a Rural Agricultural Community. Environ Health Perspect 125:333-341
Smith, Marissa N; Workman, Tomomi; McDonald, Katie M et al. (2017) Seasonal and occupational trends of five organophosphate pesticides in house dust. J Expo Sci Environ Epidemiol 27:372-378
Stanaway, Ian B; Wallace, James C; Shojaie, Ali et al. (2017) Human Oral Buccal Microbiomes Are Associated with Farmworker Status and Azinphos-Methyl Agricultural Pesticide Exposure. Appl Environ Microbiol 83:
Shaffer, Rachel M; Smith, Marissa N; Faustman, Elaine M (2017) Developing the Regulatory Utility of the Exposome: Mapping Exposures for Risk Assessment through Lifestage Exposome Snapshots (LEnS). Environ Health Perspect 125:085003
Peter, Beate; Wijsman, Ellen M; Nato Jr, Alejandro Q et al. (2016) Genetic Candidate Variants in Two Multigenerational Families with Childhood Apraxia of Speech. PLoS One 11:e0153864
Kim, Hee Yeon; Wegner, Susanna H; Van Ness, Kirk P et al. (2016) Differential epigenetic effects of chlorpyrifos and arsenic in proliferating and differentiating human neural progenitor cells. Reprod Toxicol 65:212-223

Showing the most recent 10 out of 109 publications