In preliminary analysis of the home based environmental intervention trial currently being conducted by the Center, we have found that indoor airborne PM was reduced by 31-42% and that cockroach allergen was reduced 45%. Building on this success we will test an intervention that is heavily behavioral, intended to reduce particulate sources and increase use of room air filters. This CPBR randomized controlled intervention trial is designed to compare the effectiveness of a targeted home-based particulate and allergen control behavioral education program to a traditional office-based education in decreasing home allergen and particulate levels and asthma symptoms in asthmatic children and who are exposed to ETS on a regular basis in their home. We will recruit 120 children aged 6-12 years with currently active asthma who report regular ETS exposure in the home. Each child and their family will undergo a baseline evaluation that will include questionnaires, allergy skin tests, spirometry, and a home visit to evaluate particulate and allergen control behaviors and settled dust allergen measurements. After receiving traditional particulate and allergen control education in a clinic setting, participants will be randomized to a Usual Care Group or an Intervention Group. The Intervention Group will receive a home-based behavioral education and coaching program provided by trained environmental health coaches. The intervention will be tailored to the individual particulate and allergen exposure profile of each child. Particulate control interventions will target the child's particulate exposure risk profile based on the home evaluation data. Allergen control interventions will address environmental exposure to dust mites, cockroaches, cats and dogs. Telephone interviews will evaluate symptoms and behaviors at 3, 6, 9 and 12 months post randomization. The primary outcome will be change in particulate levels and target environmental allergens in the home and change in asthma-related quality of life. Secondary outcomes include adherence with environmental control recommendations, rhinoconjunctivitis-related quality of life, FEV1, changes in other environmental allergens and particulates, self-efficacy for environmental allergy, and particulate control and healthcare utilization.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Research Program Projects (P01)
Project #
5P01ES009606-08
Application #
7188071
Study Section
Special Emphasis Panel (ZES1)
Project Start
Project End
Budget Start
2005-11-01
Budget End
2006-10-31
Support Year
8
Fiscal Year
2006
Total Cost
$147,923
Indirect Cost
Name
Johns Hopkins University
Department
Type
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Williams, D' Ann L; McCormack, Meredith C; Matsui, Elizabeth C et al. (2016) Cow allergen (Bos d2) and endotoxin concentrations are higher in the settled dust of homes proximate to industrial-scale dairy operations. J Expo Sci Environ Epidemiol 26:42-7
Bose, Sonali; Breysse, Patrick N; McCormack, Meredith C et al. (2013) Outdoor exposure and vitamin D levels in urban children with asthma. Nutr J 12:81
Levin, Albert M; Mathias, Rasika A; Huang, Lili et al. (2013) A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations. J Allergy Clin Immunol 131:1176-84
Myers, Rachel A; Himes, Blanca E; Gignoux, Christopher R et al. (2012) Further replication studies of the EVE Consortium meta-analysis identifies 2 asthma risk loci in European Americans. J Allergy Clin Immunol 130:1294-301
Huang, Weiguo; Besar, Kalpana; Lecover, Rachel et al. (2012) Correction to Highly Sensitive NH(3) Detection Based on Organic Field-Effect Transistors with Tris(pentafluorophenyl)borane as Receptor. J Am Chem Soc 134:18149
Huang, Weiguo; Besar, Kalpana; LeCover, Rachel et al. (2012) Highly sensitive NH3 detection based on organic field-effect transistors with tris(pentafluorophenyl)borane as receptor. J Am Chem Soc 134:14650-3
Butz, Arlene M; Breysse, Patrick; Rand, Cynthia et al. (2011) Household smoking behavior: effects on indoor air quality and health of urban children with asthma. Matern Child Health J 15:460-8
Tremblay, Noah J; Jung, Byung Jun; Breysse, Patrick et al. (2011) Digital Inverter Amine Sensing via Synergistic Responses by n and p Organic Semiconductors. Adv Funct Mater 21:4314-4319
Hansel, Nadia N; Matsui, Elizabeth C; Rusher, Robert et al. (2011) Predicting future asthma morbidity in preschool inner-city children. J Asthma 48:797-803
McCormack, Meredith C; Breysse, Patrick N; Matsui, Elizabeth C et al. (2011) Indoor particulate matter increases asthma morbidity in children with non-atopic and atopic asthma. Ann Allergy Asthma Immunol 106:308-15

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